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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP
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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP

Axsome Therapeutics said on Monday its experimental drug to treat agitation related to Alzheimer's disease succeeded in one of the two late-stage studies and failed to meet the main goal of the second trial.

Shares of the drug developer, which was testing the treatment, AXS-05, dropped 12% in premarket trading, Reuters reported.

The agitation is a symptom that causes emotional distress as well as verbal and physical aggressiveness.

The treatment significantly delayed the time to relapse in agitation as measured on a disease severity scale in one study, but did not demonstrate statistical significance in delaying agitation in another late-stage trial.

AXS-05 was safe and well tolerated in both the studies, the company said.

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New Observations Show Asteroid Resembling a Spinning Hockey Puck

This composite image of asteroid 2024 YR4 was captured with the Gemini South telescope in Chile. (International Gemini Observatory/NOIRLab/NSF/AURA/M. Zamani via AP)
This composite image of asteroid 2024 YR4 was captured with the Gemini South telescope in Chile. (International Gemini Observatory/NOIRLab/NSF/AURA/M. Zamani via AP)
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New Observations Show Asteroid Resembling a Spinning Hockey Puck

This composite image of asteroid 2024 YR4 was captured with the Gemini South telescope in Chile. (International Gemini Observatory/NOIRLab/NSF/AURA/M. Zamani via AP)
This composite image of asteroid 2024 YR4 was captured with the Gemini South telescope in Chile. (International Gemini Observatory/NOIRLab/NSF/AURA/M. Zamani via AP)

The asteroid that once had a small chance of striking Earth and now might slam into the moon resembles a spinning hockey puck, scientists said Tuesday.
A team of astronomers used the Gemini South Observatory in Chile to observe asteroid 2024 YR4 in multiple wavelengths as it zoomed away from Earth in February, barely 1 1/2 months after its discovery. They created a 3D image of it based on their findings, The Associated Press reported.
The nearly 200 foot (60-meter) asteroid looks more like a flat disk — or not-quite-round hockey puck — than a potato. It also has a rapid rotation rate of about once every 20 minutes.
“This find was rather unexpected since most asteroids are thought to be shaped like potatoes or toy tops rather than flat disks,” the research team lead, Bryce Bolin from Eureka Scientific said in a statement.
Scientists said it most likely originated in the main asteroid belt between Mars and Jupiter, and is rich in silicates.
At one point earlier this year, NASA and the European Space Agency put the odds of the asteroid striking Earth in 2032 at 3%. It's now down to virtually zero for the next century, but there's a 3.8% chance it could strike the moon instead. Even if that happens, NASA assures the moon's orbit will not be altered.
The asteroid —- which swings our way every four years — will be too far away by next week for ground telescopes to see. The Webb Space Telescope will take another look later this month or next.
Scientists consider all this good practice for when a potentially killer asteroid heads our way.