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French Scientists Probe mRNA's Potential to Fight Cancer

While mRNA was discovered in the early 1960s, it rose to global prominence when it was used in some Covid vaccines. JEAN-FRANCOIS MONIER / AFP
While mRNA was discovered in the early 1960s, it rose to global prominence when it was used in some Covid vaccines. JEAN-FRANCOIS MONIER / AFP
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French Scientists Probe mRNA's Potential to Fight Cancer

While mRNA was discovered in the early 1960s, it rose to global prominence when it was used in some Covid vaccines. JEAN-FRANCOIS MONIER / AFP
While mRNA was discovered in the early 1960s, it rose to global prominence when it was used in some Covid vaccines. JEAN-FRANCOIS MONIER / AFP

Inside a lab in the French city of Orleans, scientists are testing out the limits of molecules in our body called messenger RNA -- best known for being used in Covid-19 vaccines -- in the hopes of finding a breakthrough treatment for a particularly deadly cancer.

Messenger RNA, or mRNA, are molecules that carry genetic information from the DNA in every cell in the body to create specific proteins, AFP said.

"For cancer, this message will stimulate the patient's ability to effectively fight tumors," Dimitri Szymczak, project manager of French research institute INSERM's ART lab in Orleans, told AFP.

While mRNA was discovered in the early 1960s, it rose to global prominence when scientists used it to swiftly develop next-generation vaccines during the Covid pandemic, earning the medicine Nobel prize in 2023.

Today, most research in the field is focused on developing vaccines to fight cancer, but mRNA holds "many other possibilities," the ART lab's head Chantal Pichon said.

"It can be used to boost immunity, compensate for malfunctioning cells," target rare or genetic diseases -- and even treat allergies, she added.

There are more than 200 mRNA clinical trials being conducted by both big pharma firms and new start-ups around the world, many of them in the United States, China and Japan, Pichon said.

But France has "some of the best fundamental research teams working on mRNA", she added.

At the ART lab in Orleans, the scientists are making different kinds of mRNA to "test them on cells to check they are not toxic and that they work", Szymczak said.

Bunker buster

The RNA used in experiments are usually produced in test tubes, a costly process often patented by US companies.

However, some of the lab's scientists are seeking an alternative by creating the RNAs in yeast, which has the potential to slash costs by 10 to 50 times.

But these RNAs then need to be cleaned and checked to make sure they meet the requirements of the pharmaceutical industry.

Another team is trying to find a new treatment for pancreatic cancer, which has an extremely low survival rate after being diagnosed.

The survival rate has risen "from five percent in 2000 to 10 percent today", ART gastroenterologist Birane Beye said.

The only slight improvement over two decades of effort shows "that therapies like chemotherapy and immunotherapy aren't working very well", he added.

Seeking a breakthrough, French scientists are trying to combine an mRNA vaccine with ultrasound technology.

"The idea is to use the mRNA to teach immune cells to defend themselves against this very aggressive cancer," Beye explained.

First, a powerful ultrasound is used to "create vibrations inside the tissue that generate gas bubbles", he said.

"When these bubbles burst, they destroy the barrier surrounding the pancreatic cancer -- which is a bit like a bunker -- allowing the mRNA vaccine to penetrate the tumour."

So far, they have shown that ultrasounds can be used on the pancreas -- and that this technique can improve the results of conventional treatments.

Next up, the scientists hope they can use the power of mRNA to increase the survival of pancreatic cancer patients.

Thursday is World Pancreatic Cancer Day, which aims to spread awareness of the deadly cancer.

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Varieties

Food Industry Pushes Back on WHO Guidance for Products with Added Color, Sweeteners

Around 11 million deaths a year are linked to unhealthy diets, according to the agency, based on data from a global study. (Getty Images)
Around 11 million deaths a year are linked to unhealthy diets, according to the agency, based on data from a global study. (Getty Images)
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Food Industry Pushes Back on WHO Guidance for Products with Added Color, Sweeteners

Around 11 million deaths a year are linked to unhealthy diets, according to the agency, based on data from a global study. (Getty Images)
Around 11 million deaths a year are linked to unhealthy diets, according to the agency, based on data from a global study. (Getty Images)

Governments should consider regulating foods that include added colors, flavors or sweeteners designed to make the product more appealing to consumers, according to new draft World Health Organization guidance that has sparked swift pushback from the food industry.

The WHO draft aims to help governments identify which foods should be consumed in moderation as part of a healthy diet – and which products could be subject to measures like warning labels or taxes, depending on national priorities.

The new draft food-profiling model, published last week, marks the first time the UN health agency has included this type of ‌ingredient in its guidance, ‌previously only focused on nutritional content, including fat and salt.

“This draft ‌goes ⁠beyond traditional nutrient ⁠profiling by recognizing that foods may need to be considered not only for their nutrient content, but also for other aspects of their formulation” in order to prevent diet-related disease, said Katrin Engelhardt, technical officer at the WHO's department of nutrition and food safety.

Around 11 million deaths a year are linked to unhealthy diets, according to the agency, based on data from a global study.

The proposed new model is also the WHO’s attempt to guide member states through an increasingly polarized debate ⁠about ultra-processed foods (UPFs), a class of food or drink made using processing ‌techniques, additives and industrial ingredients, which often contain little ‌whole food. Examples include carbonated soft drinks or instant noodles.

BEYOND NUTRIENTS ALONE

Many food scientists say UPFs pose ‌numerous health risks but others – and the food industry – say they are defined too widely, ‌which risks demonizing healthy products.

The International Food and Beverage Alliance, an organization representing major multinational food and beverage companies, said it was concerned the proposed approach shifts attention away from nutritional quality and could capture more products for potential regulation.

"Of particular concern is the potential to undermine established nutrition priorities and reformulation ‌efforts,” said IFBA Secretary General Rocco Renaldi.

Other concerns for the food industry are higher costs from reformulating products or stringent labelling requirements, as well ⁠as the risk ⁠of class-action lawsuits as seen in the United States, and higher taxes for processed food companies.

Broadly, the WHO said the model covers “industrially-produced foods to be consumed in moderation” and is a bridge between its healthy diet recommendations and government policy on individual food products.

Lindsey Smith Taillie, co-director of the Global Food Research Program at the University of Chapel Hill, North Carolina, said the point of the model was to target unhealthy foods, combining both nutrients and UPFs.

“These two frameworks have never been mutually exclusive and can and should be used by policymakers as the starting place,” she said, adding that healthiness is measured by multiple criteria.

Kraft Heinz CEO Steve Cahillane last week told Reuters that industry players should have a say.

"We're in the food business and we care about consumers deeply," Cahillane said. "And so we ought to have a seat at the table as these discussions evolve."

The WHO proposal is out for consultation until November 27.

Varieties

Pakistan Farmers in Long Fight to Make German Firms Pay for Flood Damage

Dozens of Pakistani farmers are suing German firms RWE and Heidelberg Materials in a rare bid to make big polluters pay damages for climate impacts. Aamir QURESHI / AFP
Dozens of Pakistani farmers are suing German firms RWE and Heidelberg Materials in a rare bid to make big polluters pay damages for climate impacts. Aamir QURESHI / AFP
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Pakistan Farmers in Long Fight to Make German Firms Pay for Flood Damage

Dozens of Pakistani farmers are suing German firms RWE and Heidelberg Materials in a rare bid to make big polluters pay damages for climate impacts. Aamir QURESHI / AFP
Dozens of Pakistani farmers are suing German firms RWE and Heidelberg Materials in a rare bid to make big polluters pay damages for climate impacts. Aamir QURESHI / AFP

In a Pakistani village nestled in rice fields, Abdul Hafeez Khoso remembers the vast industrial zones he saw in Germany when he visited to file a pioneering climate legal case.

"They're spreading pollution: up in the sky there are no borders, it can affect anywhere," the 43-year-old said, describing areas far larger than his village of 800 people.

"This is a problem for the whole world -- that is why it should be resolved at the global level."

Khoso and 38 other farmers from Pakistan's southern Sindh province who were devastated by "apocalyptic" flooding in 2022 are suing German energy firm RWE and cement maker Heidelberg Materials in a rare bid to make big polluters pay damages for climate impacts.

The companies are being targeted not over specific operations in Pakistan, but because of their climate-warming emissions. They are headquartered in Germany, where a recent legal case opened the door to such suits.

The litigation argues that the companies' emissions contributed to climate change and turbo-charged rain that wiped out their crops, livestock and homes.

"The year 2022 was an apocalyptic scene -- not even our elders had ever witnessed such weather," Khoso, who lives in the district of Jacobabad with his wife and toddler, told AFP.

"We had nothing left."

Both firms, which the plaintiffs estimate contributed 0.68 percent and 0.12 percent to global industrial emissions respectively, deny wrongdoing.

Khoso's case is backed by Pakistani and European organizations hoping to win compensation and build on nascent but vigorous international efforts to extract climate damages from corporations.

"We always blame natural disasters, and sometimes we blame God, but science tells us that climate change is increasing the risks and intensity of extreme weather events," said Mir Keerio, a development expert at Pakistan's HANDS Welfare Foundation, which mobilized communities for the lawsuit.

"Those who have contributed significantly to this crisis must be held accountable... we realized we must take our fight for climate justice to the major polluters."

- Debt and damages -

Climate litigation is a growing field globally, but action has so far largely targeted governments, with only a handful of firms such as Shell and cement maker Holcim facing suits for climate disaster compensations.

Lawyers say a ruling requiring a company to pay out compensation proportionate to its greenhouse gas emissions would mark a major breakthrough.

Germany's judiciary moved towards that principle last year in a case brought by a Peruvian farmer, also against RWE.

His compensation claim was rejected, but the courts left the door open to holding emitters liable.

Roda Verheyen, a German lawyer involved in both cases, told AFP the Pakistani farmers' lawsuit builds on that ruling and further accuses companies of "wrongful behavior".

"Large companies knew about the general impacts of climate change since the 1960s," said Verheyen.

"They should have exercised due diligence and actually at least tried to reduce emissions, which they didn't do enough."

The lawsuit also draws on research documenting farmers' losses in the floods, which hit a third of the country, killed 1,700 and affected 30 million Pakistanis.

Munawar Khatoon, a rare female landowner in a conservative area, said the floods struck just before the wheat harvest, submerging seeds and wiping out her family's main source of income.

"We worry about how the next generation will manage to live if this continues," the 43-year-old told AFP in her village Usman Samtio.

"Now when the rainy season comes, we feel fear."

In nearby Dadu district, litigant Abdul Khalique Laghari said the floods affected the region for years.

"To this day, we are unable to repay our debt," said the 55-year-old, who estimates he lost $14,000 in assets including his house, 40 acres (16 hectares) of crops and livestock.

"When we wake in the morning, we start getting calls from the people we owe money to," he said, pointing to crumbling walls and the remnants of flood-damaged houses.

"This has caused us serious mental harm."

- 'For justice' -

RWE and Heidelberg Materials both call the claims in the suit "unfounded".

Heidelberg Materials told AFP its operations were compliant with German laws and that firms could not be expected to retroactively face different standards.

RWE referred AFP to a statement describing the lawsuit as "yet another attempt to shift climate policy demands to German courtrooms".

"It would be a contradiction in terms if the state allowed CO2 emissions, regulated them by law and even demanded them in some cases, but at the same time allowed retroactive civil liability for them," it said.

Even if the case succeeds, an uphill battle remains for millions across Pakistan, ranked among the countries most affected by climate change despite contributing less than one percent of global emissions.

The case will be considered in a civil process likely to take years. But for the litigants, the attempt is worth it.

"This case is for justice," said Khatoon. "We hold these companies responsible for our destruction."

Varieties

This Year Set to Be One of Four Hottest on Record, UN Report Says

A tourist holds an umbrella to shelter from the sun while walking on a hot day in Tokyo on July 15, 2026. (AFP)
A tourist holds an umbrella to shelter from the sun while walking on a hot day in Tokyo on July 15, 2026. (AFP)
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This Year Set to Be One of Four Hottest on Record, UN Report Says

A tourist holds an umbrella to shelter from the sun while walking on a hot day in Tokyo on July 15, 2026. (AFP)
A tourist holds an umbrella to shelter from the sun while walking on a hot day in Tokyo on July 15, 2026. (AFP)

This year is ‌on track to be one of the four hottest on record, driven by a powerful El Niño and perpetuating a warming streak of more than a decade, a UN report showed on Monday.

Countries are preparing to meet in Türkiye from November 9 to 20 for the next round of climate talks and the World Meteorological Organization "State of the Climate" report provides the latest available data ‌to inform ‌their discussions.

Between January and September ‌this ⁠year, the global average ⁠temperature was 1.47 degrees Celsius above the pre-industrial average and could rise further due to a major El Niño, the report showed.

The WMO report, which encompasses nine data sets, showed that each of the past 12 years, including 2026, ⁠was ranked among the 12 warmest ever ‌recorded since records began ‌in around 1850.

“Every indicator here is telling the ‌same story. We're seeing the heat trapped by greenhouse ‌gasses is showing up in the ocean, in the atmosphere, in the melting of ice and the rising of sea levels,” WMO Head of Climate Information John Kennedy ‌told reporters in Geneva ahead of the conference.

The EU's Copernicus climate ⁠service ⁠already said 2026 was all but certain to become the second calendar year after 2024 to exceed the threshold of 1.5 degrees Celsius above pre-industrial levels set in the 2015 Paris Agreement.

The planet is increasingly accumulating heat, the UN report said, with ocean temperatures continuing to rise this year from 2025 all-time highs.

Global mean sea levels have also reached a record this year as glaciers and ice sheets melt and seawater expands as it heats, the report said.