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Encouraging Trial Results for AstraZeneca's New Weight-Loss Pill

The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
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Encouraging Trial Results for AstraZeneca's New Weight-Loss Pill

The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)

A new pill developed by the British pharma firm AstraZeneca appears to help people lose a similar amount of weight to other GLP-1 oral drugs, trial results showed Monday.

If confirmed by further research, the pill could mark AstraZeneca's entrance into the massively lucrative weight-loss drug market currently dominated by Denmark's Novo Nordisk and American giant Eli Lilly.

The astronomical popularity of the appetite suppressing injectable drugs called GLP-1 agonists has kicked off a race to produce tablet versions that easier to take.

AstraZeneca's new pill, called elecoglipron, resulted in weight loss "comparable to that reported for other oral" GLP-1 drugs, according to phase 2 trial results published in the Lancet medical journal.

Side effects recorded during the randomized trial, which had 310 participants, were also similar to those seen for other GLP-1 pills, with nausea being the most common.

For overweight or obese adults without diabetes, the pill resulted in "average weight reductions of up to 10.5 percent at 26 weeks and 11.8 percent at 36 weeks in the highest-dose group," said Marie Spreckley of the University of Cambridge.

But the weight management researcher -- who was not involved in the study -- emphasized the phase 2 trial was not mainly designed to compare the pill to other anti-obesity drugs.

"Larger and longer phase 3 trials will therefore be needed to confirm the durability of these effects, establish longer-term safety and tolerability, and determine its place within the growing range of obesity and diabetes treatments," she explained.

AstraZeneca will face stiff competition -- Novo Nordisk and Eli Lilly have already developed pill versions of their hugely successful drugs.

The oral form of Eli Lilly's popular Mounjaro GLP-1 drug was approved in April in the United States, where it is sold under the brand name Foundayo.

The pill version of Novo Nordisk's blockbuster drug Wegovy is already available in the US and was given the green light by European Union health authorities last month.

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Bear Hunt Continues as Japanese City Shuts Schools for Second Day

Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
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Bear Hunt Continues as Japanese City Shuts Schools for Second Day

Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)

The hunt for a black bear spotted more than a dozen times in the Japanese city of Utsunomiya continued on Tuesday as all 94 municipal primary and middle schools were closed for a second straight day.

The adult bear, with an estimated weight of about 100 kg (220 lbs), was last seen early on Tuesday morning some 700 meters (765 ‌yards) from ‌a university campus, according to ‌the ⁠city.

The same bear ⁠is believed to have been seen on Saturday evening in the first-ever ursine sighting in the city about 100 km (60 miles) north of Tokyo.

Bear attacks, including in urban areas, have increased in Japan, prompting the government to set ⁠up a task force this ‌year to reduce casualties.

‌In the 2025 fiscal year, the country reported a record ‌238 victims, including 13 deaths, according ‌to the environment ministry.

Asiatic black bears are listed as a vulnerable species globally, but their numbers are estimated to have tripled in Japan since 2012, helped by ‌a decline in hunting.

An Utsunomiya city official said a group including ⁠municipal ⁠and prefectural staff, the fire department and members of the hunters' association were continuing to search for the bear.

Depending on where the animal is found, they will decide whether to tranquilize, shoot, or trap it for release, the official said.

Experts say climate change has reduced harvests of bears' natural food like acorns and beechnuts, while the depopulation of rural areas and the proliferation of abandoned farmland have emboldened them to seek food near human settlements.

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Italian Commuters Find a Moment of Peace on a Cable-Guided Ferry Sketched by Leonardo Da Vinci

Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
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Italian Commuters Find a Moment of Peace on a Cable-Guided Ferry Sketched by Leonardo Da Vinci

Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)

The ferry glides from one bank of northern Italy's Adda River to the other, guided by a cable and pulled by currents, offering harried commuters five minutes of serenity and an alternate route now that a bridge closure has backed up traffic.

Called “Leonardo’s Ferry,” the mechanism of the so-called reaction ferry was designed five centuries ago and immortalized by the Renaissance genius himself in a drawing preserved in Windsor Castle's Royal Collection outside of London.

It is the last remaining of its kind along the Adda River, which extends from the Alps to the Po River in the Lombardy region.

“This is a mean of transport that has been here for 500 years and has always connected the two banks of the Adda,” said Massimo Zoia, one of the volunteer ferrymen who operates the vessel. “And now it has returned to its original purpose: connecting two populations living on different banks of a river."

Despite its name, it remains unclear whether Leonardo himself actually designed the ferry. What is certain, however, is that he sketched it in 1513, as part of his famed studies of waterways, including Milan's canal system.

Leonardo was one of history’s greatest polymaths, filling notebooks with designs across a range of disciplines, including flying machines that wouldn't be realized for centuries.

The ferry’s operating principle is as simple as it is ingenious, and entirely environmentally friendly.

“The river pushes us downstream. We have a cable that binds us, and by breaking down the forces, according to the parallelogram rule, which we study in high school, the force is broken down and one part becomes resistance and the other we use for lateral movement,” Zoia said.

“The rudder is used to adjust the inclination of the ferry so that it better absorbs the stream that hits us and makes us move,” he said.

The ferry is run by the town of Imbersago, and runs to the town of Villa d’Adda on the other side. It came close to disappearing in 2023, when its operator gave up the concession. Determined to save it, Imbersago Mayor Fabio Vergani obtained a ferryman’s license himself and, together with the local tourism association, assembled a team of volunteers.

Since 2024, they have primarily transported weekend visitors from one bank of the Adda to the other.

But they added commuter service this spring after a nearby bridge was closed for maintenance to help ease traffic congestion. It now runs from 7 a.m.-7 p.m., with a two-hour lunch break at noon. Passengers pay 1.50 euros (about $1.75) if they are on foot, 2 euros ($2.30) with a bicycle, 2.50 euros ($2.88) with a motorbike and 3.50 (around $4) for a car.

Gianpaolo Graffagnino lives in Villa d’Adda and works on the other side of the river. He has started biking to work, using the ferry as a shortcut.

“Right now this is the fastest system, but above all the nicest because you get three minutes of peace,” he said.

Mauro Carnati drove his Maserati onto the ferry to bring his daughter to school on the other side, avoiding a long detour caused by the bridge closure.

“It’s true that we spend a little money, and it’s not possible every day, but the romance and added value of the Adda and the ferry are truly amazing. It makes for a better start to the day,” he said.

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Tourist Trap… Two Ice Creams For €44 in Rome

US tourist couple complains two cups of ice cream cost 44 euros in Rome (Nicole Ann/Facebook)  
US tourist couple complains two cups of ice cream cost 44 euros in Rome (Nicole Ann/Facebook)  
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Tourist Trap… Two Ice Creams For €44 in Rome

US tourist couple complains two cups of ice cream cost 44 euros in Rome (Nicole Ann/Facebook)  
US tourist couple complains two cups of ice cream cost 44 euros in Rome (Nicole Ann/Facebook)  

Near Piazza Navona in Rome, a US tourist couple were charged €44 for two ice creams eaten at the counter, sparking online anger over 'tourist trap' prices, according to euronews.

The episode, recounted on social media by Nicole Ann from Florida, quickly drew users' attention, sparking a heated online debate about the relationship between tourism and price transparency in one of Rome's most visited areas.

The woman explained that she and her husband had stopped at the “Don Nino” ice cream parlor in Via di Tor Millina to order two cups, each with three flavors.

While the ice creams were being prepared, staff are said to have added other products, including macarons and pistachio cannoli, without it being immediately clear that these were chargeable extras. When it was time to pay, a surprise was awaiting.

“I thought they had said 14 euros,” Nicole wrote in a Facebook group offering travel tips for people visiting Rome, explaining that she only realized the actual amount after checking the receipt.

The receipt posted online shows that the two portions, listed as maxi, cost twelve euros each. On top of this came supplements for whipped cream, macarons and pistachio cannoli, bringing the total to 44 euros for an order consumed without table service.

In her post, the tourist described the experience as a “tourist trap.”

Responding to the many comments she received, she nevertheless made it clear that she does not intend to contest the payment, admitting that she should have checked the price more carefully before buying. She also said she had travelled to other parts of Italy without ever encountering similar prices for an ice cream.

The post quickly went viral, attracting hundreds of reactions. Hundreds of people commented on the episode, which was shared across the web and picked up by several online newspapers.

Many users expressed solidarity with the American couple, while others pointed out that in areas with the highest concentration of tourists, prices can be significantly higher than in other parts of the city.