Scientists Find New Clues to Reversal of Alzheimer's Brain Damage

Elderly women sit at a park in downtown Shanghai March 16, 2012. REUTERS/Carlos Barria/File Photo
Elderly women sit at a park in downtown Shanghai March 16, 2012. REUTERS/Carlos Barria/File Photo
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Scientists Find New Clues to Reversal of Alzheimer's Brain Damage

Elderly women sit at a park in downtown Shanghai March 16, 2012. REUTERS/Carlos Barria/File Photo
Elderly women sit at a park in downtown Shanghai March 16, 2012. REUTERS/Carlos Barria/File Photo

Scientists studying the strongest genetic risk factor for Alzheimer's disease say they have new clues to how it works and how its damaging effects on the brain could potentially be reversed.

Researchers have found a noninvasive way to identify and study cells in the body that contribute to age-related disorders ⁠such as cancer, tissue degeneration, and inflammatory diseases.

These so-called senescent cells have stopped dividing and growing but for some reason have not died, as would be expected of old cells. Instead, they undergo significant changes to their shape, metabolic processes, and gene activity, according to Reuters.

Earlier methods of studying these cells would destroy them, the researchers noted in a report of the study in Nature Aging.

Using an analytical technique known as Raman microscopy, which reveals the biochemical composition of cells without harming them, and analyzing individual cells’ ⁠genetic activity, the researchers were able to identify unique “barcodes” of senescent cells.

The study was done in mouse cells. The researchers are now working on adapting it for use with human tissue.

“You can imagine that one day we may develop an endoscope that can look inside your body and identify cellular senescence,” Jeon Woong Kang of MIT, one of the senior authors of the study, said in a statement.

Study leader Peter So of MIT noted that senescence “is ⁠not just a pathological condition.”

While it can also contribute to sagging skin and muscle weakness in aging individuals, cellular senescence plays critical beneficial roles in embryonic development and tissue regeneration, the researchers noted.

The research is part of a National Institutes of Health initiative called the Cellular Senescence Network.

“The idea behind the NIH Cellular Senescence Network is to take a very comprehensive approach to understand senescence and identify senescent cells, because it plays a role in so many normal physiological conditions and many pathological conditions,” So said.



Dozens of Orangutans Saved from Indonesia Blazes

A 20-year-old orangutan tries to escape as members of the BKSDA (Natural Resources Conservation Agency), the Borneo Orangutan Survival Foundation (BOSF) and the World Wide Fund for Nature (WWF) Indonesia evacuate it due to forest and land fire, in Hampangen Village, Katingan Regency, Central Kalimantan, on October 17, 2026. (Photo by REINA / AFP)
A 20-year-old orangutan tries to escape as members of the BKSDA (Natural Resources Conservation Agency), the Borneo Orangutan Survival Foundation (BOSF) and the World Wide Fund for Nature (WWF) Indonesia evacuate it due to forest and land fire, in Hampangen Village, Katingan Regency, Central Kalimantan, on October 17, 2026. (Photo by REINA / AFP)
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Dozens of Orangutans Saved from Indonesia Blazes

A 20-year-old orangutan tries to escape as members of the BKSDA (Natural Resources Conservation Agency), the Borneo Orangutan Survival Foundation (BOSF) and the World Wide Fund for Nature (WWF) Indonesia evacuate it due to forest and land fire, in Hampangen Village, Katingan Regency, Central Kalimantan, on October 17, 2026. (Photo by REINA / AFP)
A 20-year-old orangutan tries to escape as members of the BKSDA (Natural Resources Conservation Agency), the Borneo Orangutan Survival Foundation (BOSF) and the World Wide Fund for Nature (WWF) Indonesia evacuate it due to forest and land fire, in Hampangen Village, Katingan Regency, Central Kalimantan, on October 17, 2026. (Photo by REINA / AFP)

Dozens of critically endangered orangutans have been rescued in recent weeks from rampant wildfires burning across Indonesia, conservation groups said.

The fires have triggered a months-long pollution spell that has closed schools, fueled a surge in respiratory conditions both among humans and animals, and restricted outdoor activities in Indonesia, Malaysia, Singapore and East Timor.

Pollution levels again ranged from unhealthy to very unhealthy across the region on Sunday, cloaking many areas across southern Southeast Asia in toxic haze.

Swiss-based air quality monitor IQAir again ranked Singapore and Kuala Lumpur among the world's top five most polluted major cities as fires on Borneo and Sumatra islands, intensified by a turbo-charged El Nino weather phenomenon, keep emitting smoke.

In Indonesia, groups are working to save wildlife from the fires, including orangutans.

On Saturday, the West Kalimantan conservation agency and Indonesian non-profit YIARI said a team evacuated 51 orangutans from locations in the province from August 6 to October 19.

And figures from Indonesia's forestry ministry suggested this week that the number rescued over recent months in Kalimantan could be as high as 96.

Officials could not be immediately reached to clarify the number, according to AFP.

Members of the BKSDA (Natural Resources Conservation Agency), the Borneo Orangutan Survival Foundation (BOSF) and the World Wide Fund for Nature (WWF) Indonesia evacuate a 20-year-old orangutan due to forest and land fire, in Hampangen Village, Katingan Regency, Central Kalimantan, on October 17, 2026. (Photo by REINA / AFP)

The latest rescue came on Saturday, when three conservation agencies rescued a 20-year-old male orangutan in Hampangen village in Central Kalimantan, on Borneo island.

"The evacuation process was carried out with great caution," the agencies said.

"After the orangutan was sedated, the medical team immediately conducted a health examination before taking the animal to the... rehabilitation center," it said.

Indonesia's transport ministry also said around 2,400 flights across the country have been affected by the haze since mid-August.

"Haze reduces visibility around airports, which can lead to delays, disruptions, and even flight cancellations. Every operational decision is made with safety as the top priority," the ministry said.


China’s Tourists Flock to Experience Pretend Typhoon as ‘Dark Tourism’ Flourishes

Participants brace for surging water in a flash flood simulator at the Lvxing center in Hangzhou (Reuters)
Participants brace for surging water in a flash flood simulator at the Lvxing center in Hangzhou (Reuters)
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China’s Tourists Flock to Experience Pretend Typhoon as ‘Dark Tourism’ Flourishes

Participants brace for surging water in a flash flood simulator at the Lvxing center in Hangzhou (Reuters)
Participants brace for surging water in a flash flood simulator at the Lvxing center in Hangzhou (Reuters)

When Leon Lv was looking for somewhere to travel last year, she turned to the Chinese social media app RedNote for ideas. The algorithm took her to videos of people struggling to survive typhoon-strength winds and flash floods.

“I never experienced a typhoon. I don’t know how it will feel and what will happen. I just have seen it on the news,” said the 28-year-old from Chongqing in southwest China. “So that’s why I want to go there to have a safe place to experience it and learn something.”

She travelled more than 1,300 kilometers to Hangzhou in the east, and joined a group of 20 to take part in a disaster simulation that featured a typhoon-fueled flooding scenario, according to The Guardian.

Standing in a simulated flood, her mind momentarily went blank as hundreds of tons of water swept people off their feet, and carried them towards a safety barrier.

As the surge hit, she forgot she was in a simulation. “One thing I learned is how to stay calm and protect myself during a flood. I learned how to use the right body position to stay safe,” she said. “No book and no school [can] teach me like that.”

Across Chinese social platforms phrases like “paying to suffer”, or “paying to buy fear” are trending online as part of a wave of interest in experiences known as “dark tourism.”

Lvxing Base, a company in Hangzhou offering simulated disaster experiences has gone viral. The founders spent 10 years making documentaries in some of the world’s most extreme environments.

At a 200,000 square meter facility, which opened in 2024, they simulate extreme weather conditions like typhoons and mudslides, giving participants the experience of what it would be like in a disaster.

“I don’t deny that many people come because they want excitement,” said general manager Wang Kuanghan. "They want to see what this place is like, what a real typhoon and torrential rain feel like, and whether they themselves can withstand it. Most of our individual customers are between 20 and 30 years old.”

It plans to open five more centers across China within the next three years. It also plans to create earthquake and fire simulations.

Extreme weather has become increasingly common in China. In 2025, China recorded its highest number of hot days since records began, and was hit by 10 typhoons, well above the long-term annual average.

China’s ministry of emergencies reported that 67 million people were affected by such disasters across the country.

The new generation of Chinese travelers want to experience a place rather than simply see famous attractions,” said Robert Li, director of the School of Hotel and Tourism Management at the Chinese University of Hong Kong.

But some travelers have found a way to blend the two approaches; rather than indulging in the white-knuckle ride of a simulated typhoon, they are travelling to real sites of death and destruction.

In May 2008 a magnitude 8.0 earthquake devastated towns in China’s Sichuan province, killing more than 70,000 people.

Alice, a 30-year-old writer from Sichuan walked around Beichuan, one of the affected towns, the ruins of which the government had preserved. Metal beams hold collapsed buildings in place for the public to visit. She saw the site where schools collapsed, crushing students inside.

“I felt scared because of the power of nature and how many children and students could not escape from it,” said Alice, who plans to start a Chinese language Substack account detailing her journeys into tragedy. “Everything was so broken. It became like a ghost town, because nobody lives in the old town anymore.”

Alice believes dark tourism helps a country reconcile with its past, even if the government decides what can be remembered.


Japan to Launch Historic Round-trip Mission to Mars Moon

(FILES) A vehicle assembly building is seen at the Tanegashima Space Center in Minamitane, Kagoshima prefecture on August 13, 2026. (Photo by Yuichi YAMAZAKI / AFP)
(FILES) A vehicle assembly building is seen at the Tanegashima Space Center in Minamitane, Kagoshima prefecture on August 13, 2026. (Photo by Yuichi YAMAZAKI / AFP)
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Japan to Launch Historic Round-trip Mission to Mars Moon

(FILES) A vehicle assembly building is seen at the Tanegashima Space Center in Minamitane, Kagoshima prefecture on August 13, 2026. (Photo by Yuichi YAMAZAKI / AFP)
(FILES) A vehicle assembly building is seen at the Tanegashima Space Center in Minamitane, Kagoshima prefecture on August 13, 2026. (Photo by Yuichi YAMAZAKI / AFP)

Japanese scientists are readying a mission to Mars's moons to retrieve samples that could help unlock the origins of the Solar System and life on Earth, in what aims to be the first round trip to the Martian region.

The unmanned Martian Moons eXploration (MMX) probe, a collaboration with US and European space agencies as well as numerous universities and tech companies, could also help lay the groundwork for eventual human exploration.

The flagship H3 rocket carrying the MMX is set to blast off from the Tanegashima Space Center Tuesday at 4:41 am (1941 GMT Monday), according to the Japan Aerospace Exploration Agency (JAXA).

The spacecraft will arrive near Mars one year later, where it will orbit its moon Phobos for up to three years before landing and collecting at least 10 grams (0.35 ounces) of material from the surface.

A rover dubbed IDEFIX -- the French name for the comic hero Asterix's dog -- will first conduct surface observations aimed at ensuring a safe landing.

"The sampling (from) Phobos is of course the world's first, but it means... this is the first round trip to the Martian system," MMX's project manager Yasuhiro Kawakatsu told AFP.

JAXA said the mission will also explore the possibility of using Phobos as a "natural space station" by establishing the requirements for a round trip to Mars -- something "essential for crewed Mars exploration".

It will also observe the Red Planet's moon Deimos, although it will not land on it, before returning to Earth.

JAXA hopes the mission will reveal how Mars and its two moons formed, a key piece of knowledge in working out how the Solar System was born.

One theory for the origin of the Martian moons -- the "giant impact" hypothesis -- is that they formed after a celestial body collided with Mars.

The "capture" hypothesis, meanwhile, postulates that the moons are asteroids captured by Mars's gravity.

Determining which is right will help reveal "how a habitable environment for life might have arisen on the terrestrial planets", JAXA said, referring to the four rocky worlds closest to the Sun -- Mercury, Venus, Earth and Mars.

"MMX will shed light on the transport mechanisms that delivered water, volatiles, and organic compounds from the outer Solar System to the inner rocky planet region -- processes that may have played a key role in making these worlds habitable," said Patrick Michel, a French astrophysicist working on IDEFIX.

"If Phobos and Deimos are indeed remnants of these early delivery systems, they may hold clues to the origins of life itself, or, to be more correct, to the transport of the materials that were key to the emergence of life on rocky planets," he told AFP.

MMX is a collaboration with France's National Centre for Space Studies (CNES), the German Aerospace Center (DLR), NASA, the European Space Agency (ESA), and about 20 universities and tech companies.

The development of the spacecraft's landing legs was particularly difficult, as gravity on Phobos is extremely weak, JAXA scientists say.

Japan's unmanned Smart Lander for Investigating Moon (SLIM) -- the "Moon Sniper" -- tipped over after touching down on Earth's Moon in 2024, but still transmitted data and survived several two-week lunar nights.

Japan also has experience in bringing back samples from space, including JAXA's unmanned Hayabusa-2, which returned 5.4 grams of rock and dust collected from an asteroid several hundred million kilometers from Earth in 2020.

One of the differences between JAXA's past asteroid probes and the MMX mission is that this time "we have to travel very close to Mars and return", which means escaping the planet's heavy gravity, Kawakatsu told reporters.

Phobos orbits about 6,000 kilometers above the Martian surface.

"Going deep into what we call the 'gravity well' is difficult," Kawakatsu said.

US and Chinese space agencies have been racing to be the first to return rock samples from Mars's surface back to Earth.

NASA's Perseverance rover, which has been roaming the Red Planet since 2021, has already collected samples.

The mission, however, was effectively cancelled by the administration of President Donald Trump following a vote by the US Congress in January.

China, meanwhile, has announced its Tianwen-3 spacecraft is scheduled for launch around 2028 and hopes to return Mars samples to Earth as early as 2031 -- potentially before the MMX's return.

JAXA scientists say sand and rocks from Phobos may offer a wider variety of samples than those on the planet itself, especially if it was formed by a collision between a celestial body and Mars.