The US military said late Wednesday that it had destroyed four "uncrewed aerial systems" in an area of Yemen controlled by Iran-backed Houthis.
US Central Command said on the social media site X that the systems presented an imminent threat to US and coalition forces and merchant vessels in the region.
The Iran-backed group says the ongoing campaign of attacks is designed to show solidarity with the Palestinians in Gaza.
Houthi attacks in the Red Sea have disrupted global shipping, forcing firms to re-route to longer and more expensive journeys around southern Africa, and stoked fears that the Israel-Hamas war could destabilize the wider Middle East.
The United States and Britain have carried out strikes against Houthi targets in response to the attacks on shipping.