WHO Combats Snake Bites with Anti-Venom Initiatives

A snake. AFP photo
A snake. AFP photo
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WHO Combats Snake Bites with Anti-Venom Initiatives

A snake. AFP photo
A snake. AFP photo

It took only minutes for snake expert David Williams to feel the effect of being bitten by a deadly taipan. His breathing quickly became labored, and he could only urge his colleagues at the film shoot to hurry for the antidote before falling into a coma.

The Australian expert said dryly, saved by the prompt administration of a 1,800-dollar shot to counter the snake’s venom: “If I hadn’t got it, you would not be talking to me now, but digging my grave.”

The 2007 incident in Papua New Guinea ended happily for Williams, a leading anti-venom researcher.

The majority of cases are in developing countries, where such advanced treatments are seldom available. Some 100,000 people a year die from snakebites, according to the World Health Organization (WHO).

With Williams’ support, WHO has now launched a campaign to tackle the shortage of approved anti-venoms by boosting their production and range of application while still ensuring the required standards.

Not all anti-venoms work for any bite. An Asian taipan’s bite, for example, can be countered only by one agent derived from venom of the same animal species. And serums made from the venom of Indian snakes have little effect in Africa, where up to 30,000 people die each year from bites.

Anti-venoms available in India are also of doubtful quality, contributing to the annual snakebite death toll of more than 50,000 people. Overall, the number of deaths globally is as high as for dengue fever, a disease that gets significantly more attention.

In response, WHO has started placing snakebites on the list of forgotten tropical diseases. This has increased attention paid to the misery caused and will hopefully help raise more funds in wealthy countries for the development of accessible treatments.

WHO is now working on guidelines for the safe production of effective medications and is also testing its own anti-venoms.

These are polyvalent, meaning they should be effective against bites from several types of snakes found in sub-Saharan Africa.

Nuebling explained that the first phase of the lab testing has been completed, and next there will be tests for effectiveness in mice.



French Scientists Find New Blood Type in Guadeloupe Woman

A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type. (AFP)
A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type. (AFP)
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French Scientists Find New Blood Type in Guadeloupe Woman

A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type. (AFP)
A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type. (AFP)

A French woman from the Caribbean island of Guadeloupe has been identified as the only known carrier of a new blood type, dubbed "Gwada negative," France's blood supply agency has announced.

The announcement was made 15 years after researchers received a blood sample from a patient who was undergoing routine tests ahead of surgery, the French Blood Establishment (EFS) said on Friday.

"The EFS has just discovered the 48th blood group system in the world!" the agency said in a statement on social network LinkedIn.

"This discovery was officially recognized in early June in Milan by the International Society of Blood Transfusion (ISBT)."

The scientific association had until now recognized 47 blood group systems.

Thierry Peyrard, a medical biologist at the EFS involved in the discovery, told AFP that a "very unusual" antibody was first found in the patient in 2011.

However, resources at the time did not allow for further research, he added.

Scientists were finally able to unravel the mystery in 2019 thanks to "high-throughput DNA sequencing", which highlighted a genetic mutation, Peyrard said.

The patient, who was 54 at the time and lived in Paris, was undergoing routine tests before surgery when the unknown antibody was detected, Peyrard said.

This woman "is undoubtedly the only known case in the world," said the expert.

"She is the only person in the world who is compatible with herself," he said.

Peyrard said the woman inherited the blood type from her father and mother, who each had the mutated gene.

The name "Gwada negative", which refers to the patient's origins and "sounds good in all languages", has been popular with the experts, said Peyrard.

The ABO blood group system was first discovered in the early 1900s. Thanks to DNA sequencing, the discovery of new blood groups has accelerated in recent years.

Peyrard and colleagues are now hoping to find other people with the same blood group.

"Discovering new blood groups means offering patients with rare blood types a better level of care," the EFS said.