A Broken Back Without the Fall

Photo: Tonpor Kasa/Getty Images
Photo: Tonpor Kasa/Getty Images
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A Broken Back Without the Fall

Photo: Tonpor Kasa/Getty Images
Photo: Tonpor Kasa/Getty Images

You didn't fall, and you didn't do anything strenuous. So it may come as a surprise when the bad back pain you've been experiencing turns out to be one or more broken bones in your back. "A common story is that someone bends down to put something in the dishwasher or steps off a curb a little hard and puts additional load on their spine. The weakened bone is not adequate to take that load, and it collapses," says Dr. Julia Charles, a rheumatologist and bone cell researcher at Harvard-affiliated Brigham and Women's Hospital.

What weakens the spine?
Your spine contains about 30 bones called vertebrae, stacked on top of each other like a roll of quarters. Each vertebra consists of an external bone surface (like plaster), and an inside filled with a honeycomb of support rods called trabeculae.

The body constantly renews these structures, using two groups of specialized cells: osteoclasts, which break down old bone, and osteoblasts, which build new bone.

Over time, the osteoblasts can't keep pace, and the trabeculae become narrower and weaker. For some people, the bones become especially thin and brittle — a condition called osteoporosis.

In women, menopause is partly to blame. "We know that around menopause, osteoclasts are more active, and osteoblasts slow down," says Dr. Charles.

Compression fractures
When a vertebra isn't strong enough to support the load you place on it, it may collapse. That's called a compression fracture.

Sometimes the fracture is sudden and comes with sharp, excruciating pain that can sideline you for months.

"But the majority of the fractures don't have symptoms," Dr. Charles explains. "It's not uncommon for a chest x-ray or CT scan to show an old compression fracture you didn't know you had."

Long-term risks
When one vertebra fractures, there's a high risk that another will. Each fracture brings a slight loss of height and a reduced ability to bend.

Multiple fractures contribute to a rounding of the back known as dowager's hump (dorsal kyphosis). The condition significantly increases the risk for disability, as well as difficulty digesting food or breathing.

Treatment
If an x-ray shows you've suffered a compression fracture, your doctor may recommend taking over-the-counter painkillers such as acetaminophen (Tylenol) or ibuprofen (Advil, Motrin).

For more severe pain, your doctor may recommend a short course (up to four weeks) of a nasal spray called calcitonin (Miacalcin), which inhibits bone breakdown; or possibly opioids, such as oxycodone (OxyContin).

Lingering pain
Pain often lasts up to six weeks. For people whose pain lasts more than six months, a treatment called vertebral augmentation (such as kyphoplasty) may be considered. It's a little like pouring cement into a broken vertebra to make it stronger.

But Dr. Charles says its effectiveness is debated. "There are good studies showing it's not helpful in controlling pain from the average sudden-onset compression fracture. Still, it's possible some people may benefit," she says.

Long-term outlook
Think of a compression fracture as a wake-up call to seek treatment for osteoporosis. Treatment for osteoporosis could include any of the following:

Taking prescription medications. Examples include oral alendronate (Fosamax) or intravenous zoledronic acid (Reclast) to increase bone density. These may lower the risk for another compression fracture by up to 70%.

Getting enough calcium. Calcium is important for maintaining bone health. If your diet contains 1,200 milligrams of calcium per day, that's sufficient. If your diet contains less than this, add calcium pills at each meal to make up the difference, Dr. Charles says.

Taking vitamin D. We need vitamin D to absorb calcium. Dr. Charles recommends 800 international units per day. You may get some of that through milk fortified with vitamin D. Vitamin D3 capsules can provide the rest.

Exercising. Weight-bearing exercise, like walking, helps build bone. "But we don't have good data on what's safe when you have osteoporosis," Dr. Charles warns. "Resistance bands and light weights are fine, but try not to load the spine."

What if you put off treatment? "Your risk for another compression fracture increases fivefold, and having a compression fracture increases your risk for hip fracture as well," Dr. Charles says. "The choice not to treat osteoporosis comes with risks."

(Harvard Health Letter)



Encouraging Trial Results for AstraZeneca's New Weight-Loss Pill

The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
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Encouraging Trial Results for AstraZeneca's New Weight-Loss Pill

The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)
The logo for AstraZeneca is seen outside its North America headquarters in Wilmington, Delaware, US, March 22, 2021. (Reuters)

A new pill developed by the British pharma firm AstraZeneca appears to help people lose a similar amount of weight to other GLP-1 oral drugs, trial results showed Monday.

If confirmed by further research, the pill could mark AstraZeneca's entrance into the massively lucrative weight-loss drug market currently dominated by Denmark's Novo Nordisk and American giant Eli Lilly.

The astronomical popularity of the appetite suppressing injectable drugs called GLP-1 agonists has kicked off a race to produce tablet versions that easier to take.

AstraZeneca's new pill, called elecoglipron, resulted in weight loss "comparable to that reported for other oral" GLP-1 drugs, according to phase 2 trial results published in the Lancet medical journal.

Side effects recorded during the randomized trial, which had 310 participants, were also similar to those seen for other GLP-1 pills, with nausea being the most common.

For overweight or obese adults without diabetes, the pill resulted in "average weight reductions of up to 10.5 percent at 26 weeks and 11.8 percent at 36 weeks in the highest-dose group," said Marie Spreckley of the University of Cambridge.

But the weight management researcher -- who was not involved in the study -- emphasized the phase 2 trial was not mainly designed to compare the pill to other anti-obesity drugs.

"Larger and longer phase 3 trials will therefore be needed to confirm the durability of these effects, establish longer-term safety and tolerability, and determine its place within the growing range of obesity and diabetes treatments," she explained.

AstraZeneca will face stiff competition -- Novo Nordisk and Eli Lilly have already developed pill versions of their hugely successful drugs.

The oral form of Eli Lilly's popular Mounjaro GLP-1 drug was approved in April in the United States, where it is sold under the brand name Foundayo.

The pill version of Novo Nordisk's blockbuster drug Wegovy is already available in the US and was given the green light by European Union health authorities last month.


Wild Black Bear in Japan Captured After Multi-Day Hunt Captures the Nation’s Attention

 Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
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Wild Black Bear in Japan Captured After Multi-Day Hunt Captures the Nation’s Attention

 Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)
Police officers with shields and sticks search for a bear at a residential area after a black bear was spotted in Utsunomiya, Tochigi Prefecture, Japan, June 9, 2026. (Reuters)

The Japanese city of Utsunomiya captured a wild black bear on Tuesday after a dramatic multi-day search that gripped the nation, as local schools closed and residents were urged to stay indoors. 

The city closed all 94 municipal primary and middle schools for a second straight day on Tuesday after its first-ever bear sighting on Saturday evening.  

Authorities decided to keep schools closed again on Wednesday due to a report of a possible second bear roaming the city, an official said. 

Bear attacks have spiked in Japan, including ‌in urban areas, prompting ‌the government to set up a task ‌force ⁠this year to reduce ⁠incidents. In fiscal 2025, the country reported a record 238 casualties, including 13 deaths, according to the environment ministry. 

With about 500,000 residents, Utsunomiya, in Tochigi Prefecture, is part of the Greater Tokyo Metropolitan region, about 100 km (60 miles) north of the capital. 

When the bear resurfaced in a residential area early on Tuesday afternoon, police cars and other vehicles involved ⁠in the search promptly blocked off the vicinity. ‌For more than an hour, police officers ‌milled about, with some holding long sticks and others metal shields, as some ‌national broadcasters aired live footage filmed from helicopters. 

The adult bear, which ‌was estimated to weigh about 100 kg (220 lbs), was eventually shot with a tranquilizer gun, loaded onto a cage on a truck and driven away. The city has yet to decide what to do with it, an ‌official said. 

Around 100 km to the northeast, Iwaki, in Fukushima Prefecture, also suspended classes at three ⁠schools on Tuesday in ⁠a neighborhood where a black bear was spotted a day earlier. 

Last week, a bear attack in Fukushima city left at least four people injured, with security footage in one incident showing the animal chasing a man and throwing him to the ground. 

Asiatic black bears are listed as a vulnerable species globally, but their numbers are estimated to have tripled in Japan since 2012, aided by a decline in hunting. 

Experts say climate change has reduced harvests of natural bear food like acorns and beechnuts, while the depopulation of rural areas and the proliferation of abandoned farmland have emboldened them to seek nourishment near human settlements. 


Italian Commuters Find a Moment of Peace on a Cable-Guided Ferry Sketched by Leonardo Da Vinci

 Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
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Italian Commuters Find a Moment of Peace on a Cable-Guided Ferry Sketched by Leonardo Da Vinci

 Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)
Commuters board the “Da Vinci Ferry,” a hand-operated ferry of a type sketched by Leonardo da Vinci in the 15th century, on the Adda River between the provinces of Lecco and Bergamo, in Imbersago, Italy, Thursday, June 4, 2026. (AP)

The ferry glides from one bank of northern Italy's Adda River to the other, guided by a cable and pulled by currents, offering harried commuters five minutes of serenity and an alternate route now that a bridge closure has backed up traffic.

Called “Leonardo’s Ferry,” the mechanism of the so-called reaction ferry was designed five centuries ago and immortalized by the Renaissance genius himself in a drawing preserved in Windsor Castle's Royal Collection outside of London.

It is the last remaining of its kind along the Adda River, which extends from the Alps to the Po River in the Lombardy region.

“This is a mean of transport that has been here for 500 years and has always connected the two banks of the Adda,” said Massimo Zoia, one of the volunteer ferrymen who operates the vessel. “And now it has returned to its original purpose: connecting two populations living on different banks of a river."

Despite its name, it remains unclear whether Leonardo himself actually designed the ferry. What is certain, however, is that he sketched it in 1513, as part of his famed studies of waterways, including Milan's canal system.

Leonardo was one of history’s greatest polymaths, filling notebooks with designs across a range of disciplines, including flying machines that wouldn't be realized for centuries.

The ferry’s operating principle is as simple as it is ingenious, and entirely environmentally friendly.

“The river pushes us downstream. We have a cable that binds us, and by breaking down the forces, according to the parallelogram rule, which we study in high school, the force is broken down and one part becomes resistance and the other we use for lateral movement,” Zoia said.

“The rudder is used to adjust the inclination of the ferry so that it better absorbs the stream that hits us and makes us move,” he said.

The ferry is run by the town of Imbersago, and runs to the town of Villa d’Adda on the other side. It came close to disappearing in 2023, when its operator gave up the concession. Determined to save it, Imbersago Mayor Fabio Vergani obtained a ferryman’s license himself and, together with the local tourism association, assembled a team of volunteers.

Since 2024, they have primarily transported weekend visitors from one bank of the Adda to the other.

But they added commuter service this spring after a nearby bridge was closed for maintenance to help ease traffic congestion. It now runs from 7 a.m.-7 p.m., with a two-hour lunch break at noon. Passengers pay 1.50 euros (about $1.75) if they are on foot, 2 euros ($2.30) with a bicycle, 2.50 euros ($2.88) with a motorbike and 3.50 (around $4) for a car.

Gianpaolo Graffagnino lives in Villa d’Adda and works on the other side of the river. He has started biking to work, using the ferry as a shortcut.

“Right now this is the fastest system, but above all the nicest because you get three minutes of peace,” he said.

Mauro Carnati drove his Maserati onto the ferry to bring his daughter to school on the other side, avoiding a long detour caused by the bridge closure.

“It’s true that we spend a little money, and it’s not possible every day, but the romance and added value of the Adda and the ferry are truly amazing. It makes for a better start to the day,” he said.