Moderna Signs Deal on Variant-Adapted COVID Shots for World’s Poorest

A bottle containing the new Moderna Spikevax mRNA COVID 19 vaccine stands ready to be drawn into syringes at the centre of the Geneva University Hospitals (HUG), that opened for the public to get the forth booster dose againt COVID, in Geneva, Switzerland, 10 October 2022. (EPA)
A bottle containing the new Moderna Spikevax mRNA COVID 19 vaccine stands ready to be drawn into syringes at the centre of the Geneva University Hospitals (HUG), that opened for the public to get the forth booster dose againt COVID, in Geneva, Switzerland, 10 October 2022. (EPA)
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Moderna Signs Deal on Variant-Adapted COVID Shots for World’s Poorest

A bottle containing the new Moderna Spikevax mRNA COVID 19 vaccine stands ready to be drawn into syringes at the centre of the Geneva University Hospitals (HUG), that opened for the public to get the forth booster dose againt COVID, in Geneva, Switzerland, 10 October 2022. (EPA)
A bottle containing the new Moderna Spikevax mRNA COVID 19 vaccine stands ready to be drawn into syringes at the centre of the Geneva University Hospitals (HUG), that opened for the public to get the forth booster dose againt COVID, in Geneva, Switzerland, 10 October 2022. (EPA)

Moderna Inc has agreed to provide its new variant-adapted COVID-19 vaccine to the global scheme aiming to deliver shots to the world's poorest people.

The biotech company and vaccine alliance GAVI will cancel their existing supply deal for vaccines based on the original coronavirus strain. Instead, Moderna will supply up to 100 million doses of its new, variant-adapted vaccines at its lowest available price from 2023.

GAVI leads the COVAX initiative alongside the World Health Organization and other global bodies. The scheme has delivered 1.79 billion doses of COVID vaccine to 146 countries, including nearly 186 million doses of Moderna's original shot.

While at first the initiative struggled for shots as wealthy countries snapped up limited supply, this year it has had a glut of the original vaccines, prompting negotiations to try to better align supply with demand.

Moderna's bivalent COVID vaccine, containing both the original coronavirus strain and the BA.1 Omicron variant, has had approval from regulators worldwide.

GAVI chief executive Seth Berkley said the new agreement was a "critical step for equitable access" to allow lower income countries to use the modified vaccines as they see fit.

Many wealthier countries have started using the vaccine in booster campaigns.

Negotiations with other vaccine manufacturers to adjust supply agreements are going on, GAVI said.



Massive New Los Angeles-area Fire Balloons as Winds Pick Up

Firefighters battle the Hughes Fire near Castaic Lake, north of Santa Clarita, California, US January 22, 2025. REUTERS/Ringo Chiu
Firefighters battle the Hughes Fire near Castaic Lake, north of Santa Clarita, California, US January 22, 2025. REUTERS/Ringo Chiu
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Massive New Los Angeles-area Fire Balloons as Winds Pick Up

Firefighters battle the Hughes Fire near Castaic Lake, north of Santa Clarita, California, US January 22, 2025. REUTERS/Ringo Chiu
Firefighters battle the Hughes Fire near Castaic Lake, north of Santa Clarita, California, US January 22, 2025. REUTERS/Ringo Chiu

Powerful winds and bone-dry conditions were expected to pose a challenge to firefighters battling new wildfires in southern California on Thursday, including a new blaze that swelled over the past day, forcing tens of thousands of people to evacuate north of Los Angeles.

The Hughes fire, about 50 miles (80 km) north of Los Angeles, grew to 10,176 acres (4,118 hectares) since igniting on Wednesday morning, the California Department of Forestry and Fire Protection, or Cal Fire, said on its website.

The 4,000 firefighters battling the blaze have achieved 14% containment, a measure of the percentage of a fire's perimeter that is under control, Cal Fire added.

Crews fighting the Hughes Fire and two other massive Los Angeles blazes - Palisades and Eaton - were expected to be tested by strong Santa Ana winds of up to 50 miles (80 km) per hour with gusts reaching 65 miles (105 km) per hour and humidity levels dropping below 10% throughout the day and into Friday, forecasters said, Reuters reported.

"Dangerous fire weather conditions will persist through Friday as fuels remain extremely dry and ready to burn, with Thursday the period of greatest concern," the National Weather Service said in an advisory. "Any fire that starts can grow fast and out of control."

About 31,000 people were evacuated on Wednesday as the fire sent huge flames and plumes of smoke over a hilly terrain in the Castaic Lake area near Santa Clarita.

The Eaton and Palisades fires, which leveled entire neighborhoods on the eastern and western flanks of Los Angeles, have killed 28 people and damaged or destroyed nearly 16,000 structures over the past two weeks.

Helicopters battling the Hughes Fire scooped water out of a lake to drop on the fire while airplanes dropped fire retardant on the hills, video on KTLA television showed. Flames spread to the water's edge.

Eyewitness video showed the skies north of Los Angeles tinted orange on Wednesday afternoon as the Hughes Fire expanded rapidly.

A smaller blaze, called the Sepulveda Fire, was burning along the 405 freeway near the Getty Museum - home to numerous art treasures - in the San Fernando Valley on Thursday. The brush fire, which was 40 acres (16 hectares) and 0% contained, briefly caused part of the heavily traveled highway to be closed and some nearby residents to be evacuated overnight.

Southern California has gone without significant rain for nine months, contributing to hazardous conditions, but some rain was forecast from Saturday through Monday, possibly giving firefighters much-needed relief.

As of Thursday morning, the Eaton Fire that scorched about 14,000 acres (5,670 hectares) east of Los Angeles was 95% contained, while the larger Palisades Fire, which has consumed about 23,450 acres (9,490 hectares) on the west side of Los Angeles, stood at 70% contained, Cal Fire said.