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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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KAUST Unveils Landmark Coral Facility on Red Sea, Advancing Saudi Scientific Expertise and Marine Conservation

KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
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KAUST Unveils Landmark Coral Facility on Red Sea, Advancing Saudi Scientific Expertise and Marine Conservation

KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)
KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt. (SPA)

The King Abdullah University of Science and Technology (KAUST) launched the KAUST Coral Restoration Initiative’s large-scale coral facility, restoring and advancing one of Saudi Arabia’s most precious natural assets, reported the Saudi Press Agency on Wednesday.

On Saudi Arabia’s Red Sea coast, the KAUST Coral Restoration Initiative (KCRI) land-based nursery and research campus is now growing corals at scale. It is designed to produce up to 360,000 corals a year, to outplant more than two million corals across 100 hectares of reef at Shushah Island by 2030, and to establish a resilient reef ecosystem by 2040.

This opening of the world’s largest coral restoration facility, announced at COP31 in Antalya, arrives at a moment of acute urgency for the world’s reefs. The fourth global coral bleaching event, confirmed by NOAA as the most severe in recorded history, affected more than 84% of the world’s reef area between 2023 and 2025.

Coral reefs support around a quarter of all marine species, protect coastlines from storms and sustain the livelihoods of more than 500 million people. (SPA)

The Red Sea is the right place to start. Its corals live in some of the warmest, saltiest waters on Earth, and they hold lessons about resilience that reefs everywhere will need. KCRI combines the Red Sea’s unique corals with KAUST’s world-class marine science to learn how corals can be grown at scale and conditioned to withstand warmer water before they return to the reef.

The initiative also draws on the expertise of the Coral Research and Development Accelerator Platform (CORDAP), which works internationally to accelerate scientific and technological solutions for coral reef conservation and restoration.

KCRI brings four components together in a single restoration system, including a large-scale land-based coral nursery, sea-based nurseries, more than 50 research programs spanning coral probiotics, heat-resilient corals, robotics and AI-driven modelling and eCoral, an AI-driven digital twin of the reefscape that guides where and how every coral is planted and monitored.

Saudi scientists, divers and aquarists are playing an important role in KCRI’s restoration efforts, developing specialist expertise in coral cultivation, marine science and reef restoration. (SPA)

Saudi scientists, divers and aquarists are playing an important role in KCRI’s restoration efforts, developing specialist expertise in coral cultivation, marine science and reef restoration. Beyond its restoration activities, KCRI represents a long-term investment in Saudi Arabia’s marine science capabilities.

Coral reefs support around a quarter of all marine species, protect coastlines from storms and sustain the livelihoods of more than 500 million people. KCRI is designed to restore the Red Sea reefscape and offer a framework that coral restoration programs worldwide can adopt.

KAUST is also working with international partners on how coral diversity can be safeguarded for future generations.

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Portugal Closes All Schools and Non-Essential Services Ahead of a Major Atlantic Storm

Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
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Portugal Closes All Schools and Non-Essential Services Ahead of a Major Atlantic Storm

Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)
Heavy machinery clears the debris from a landslide along the Marocos road in Machico municipality, on the Portuguese island of Madeira, due to severe weather caused by the passage of Storm Charles, 11 November 2026. (EPA)

Portugal closed all schools and shuttered non-essential public services on Wednesday as a major Atlantic storm headed for the country's mainland.

Streets remained largely deserted ahead of the arrival of Storm Charles after the government told people to stay at home as heavy rain and rough seas were expected to batter the Portuguese coast, with wind gusts of up to 140 kph (85 mph).

It was the first time in living memory that Portugal’s roughly 8,000 schools had canceled classes nationwide over a storm forecast.

Buses without passengers drove through the country's capital, Lisbon, where some streets flooded due to clogged drains. A national supermarket chain closed its stores, while an international technology conference in Lisbon attended by around 70,000 people called off the day's events.

In January, the country's center-right government faced harsh criticism for its weak response when Storm Kristin hit central Portugal, felling thousands of trees and causing widespread property damage that is still being repaired.

The brunt of Storm Charles was expected to hit the Atlantic coast on Wednesday afternoon and evening, coming from the southwest after it had struck the Portuguese island of Madeira on Tuesday with 130 kph (81 mph) winds.

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Once the World's Fastest, Ocean Liner Will Become Largest Artificial Reef

The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
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Once the World's Fastest, Ocean Liner Will Become Largest Artificial Reef

The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)
The S.S. United States crossed the Atlantic more than 800 times. (Getty Images)

An ocean liner that is longer than the Titanic and was once the fastest on the seas is headed to a final home on the floor of the Gulf of Mexico as the world's largest artificial reef.

The S.S. United States is scheduled to be sunk Wednesday off the coast of the Florida Panhandle, fulfilling a long-planned $13.5 million project aimed at attracting more divers and fishing enthusiasts to the area while creating a home for tuna, marlin and swordfish.

The project will keep what had been a technological marvel when it made its maiden voyage in 1952 from becoming scrap metal.

The S.S. United States crossed the Atlantic more than 800 times, carrying old Hollywood stars like Grace Kelly and Elizabeth Taylor. Other passengers have included President John F. Kennedy and Britain’s former King Edward VIII. In 1968, a young Bill Clinton took it when he went to Oxford University, decades before he was elected president.

In preparation for the sinking, organizers removed the 65-foot smokestacks and plan to have them anchor a new museum that celebrates the ship. Once aboard, passengers were treated to dinners that included caviar, roast duckling, smoked ox tongue and Calf's Head en Tortue.

“It was our goal to make sure that she wasn’t lost forever,” said David Lawrence, a member of the board for the S.S. United States Conservancy, which is dedicated to preserving the ship.

The ship will be sunk without using explosives

Federal environmental and explosives rules prevent Okaloosa County, Florida, and its contractor from using explosives to scuttle the ship, said Nick Tomecek, the county's spokesperson. Concerns about inclement weather prompted officials to move up the sinking by a day.

The S.S. United States has pipes that pulled seawater into tanks as part of the system that cooled its boilers, he said, and those tanks have been removed so that once the valves are opened, water will flood the hull. Workers also have cut 10-foot by 10-foot holes in the decks, and more than 400 portholes have been removed.

The ship is to sink in about 180 feet (55 meters) of water, with its top deck about 60 feet (18 meters) below the surface — shallow enough that inexperienced divers can visit. It will settle on the floor of the waters about 25 miles (40 kilometers) southwest of Destin, between Panama City and Pensacola.

Larger than the Titanic, the ship's first voyage set a speed record

More than 3,000 workers helped build the S.S. United States in 1950 and 1951 in Virginia. An Associated Press reporter and President Harry Truman's daughter, Margaret, were among 1,700 passengers for the first voyage.

The ship's average speed for that trip was almost 41 miles (66 kilometers) per hour, besting a record set by Britain's R.M.S. Queen Mary in 1938 by 4.5 miles (7.2 kilometers) per hour, according to the AP's dispatch.

The S.S. United States set the record even though its journey ended in the face of a full gale that reached 69 miles (111 kilometers) per hour — “so strong it blew a ping pong table off the deck,” AP reported.

At 990 feet (302 meters), the ship is 108 feet (33 meters) longer than the ill-fated Titanic, which hit an iceberg and sank on its first voyage across the Atlantic.

“She really embodies and expresses this country’s best,” said Susan Gibbs, the granddaughter of the ship's designer. “She represents pride and resilience and strength and beauty.”

The ship's resting place has many artificial reefs

About 500 artificial reefs are located in the waters near where the S.S. United States will rest, Tomecek said.

Previously, the largest artificial reef came from the 2006 scuttling of an aircraft carrier, the USS Oriskany in the Gulf off of Pensacola — near enough to the S.S. United States site that an experienced diver could visit both in the same day, Tomecek said. The Oriskany, launched in 1950, was 911 feet (278 meters) in length.

“We're trying to be the best diving destination in the world,” Tomecek said.

The ship was decommissioned in 1969. Attempts by a hotel magnate and Norwegian Cruise Lines to use the ship never floated, and from 1996 until recently, it sat along a dock in Philadelphia.

“I’m just so happy that we are able to save parts of her,” Gibbs said.