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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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The Next Round of Bitter Cold and Snow will Hit the Southern US

A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
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The Next Round of Bitter Cold and Snow will Hit the Southern US

A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)
A person holds an umbrella as they walk during a winter storm, Monday, Jan. 6, 2025, in Cincinnati. (AP Photo/Joshua A. Bickel)

The next round of bitter cold was set to envelop the southern U.S. on Tuesday, after the first significant winter storm of the year blasted a huge swath of the country with ice, snow and wind.

The immense storm system brought disruption even to areas of the country that usually escape winter’s wrath, downing trees in some Southern states, threatening a freeze in Florida and causing people in Dallas to dig deep into their wardrobes for hats and gloves.

By early Tuesday, wind chill temperatures could dip into the teens to low 20s (as low as minus 10.5 C) from Texas across the Gulf Coast, according to the National Weather Service. A low-pressure system is then expected to form as soon as Wednesday near south Texas, bringing the potential of snow to parts of the state that include Dallas, as well as to Oklahoma, Arkansas and Louisiana.

The polar vortex that dipped south over the weekend kept much of the country east of the Rockies in its frigid grip Monday, making many roads treacherous, forcing school closures, and causing widespread power outages and flight cancellations.

Ice and snow blanketed major roads in Kansas, western Nebraska and parts of Indiana, where the National Guard was activated to help stranded motorists. The National Weather Service issued winter storm warnings for Kansas and Missouri, where blizzard conditions brought wind gusts of up to 45 mph (72 kph). The warnings extended to New Jersey into early Tuesday.

A Kentucky truck stop was jammed with big rigs forced off an icy and snow-covered Interstate 75 on Monday just outside Cincinnati. A long haul driver from Los Angeles carrying a load of rugs to Georgia, Michael Taylor said he saw numerous cars and trucks stuck in ditches and was dealing with icy windshield wipers before he pulled off the interstate.

“It was too dangerous. I didn’t want to kill myself or anyone else,” he said.

The polar vortex of ultra-cold air usually spins around the North Pole, but it sometimes plunges south into the U.S., Europe and Asia. Studies show that a fast-warming Arctic is partly to blame for the increasing frequency of the polar vortex extending its grip.

Temperatures plunge across the country The eastern two-thirds of the U.S. dealt with bone-chilling cold and wind chills Monday, with temperatures in some areas far below normal.

A cold weather advisory will take effect early Tuesday across the Gulf Coast. In Texas’ capital of Austin and surrounding cities, wind chills could drop as low as 15 degrees (minus 9.4 C).

The Northeast was expected to get several cold days.

Transportation has been tricky Hundreds of car accidents were reported in Virginia, Indiana, Kansas and Kentucky, where a state trooper was treated for non-life-threatening injuries after his patrol car was hit.

Virginia State Police responded to at least 430 crashes Sunday and Monday, including one that was fatal. Police said other weather-related fatal accidents occurred Sunday near Charleston, West Virginia, and Monday in Winston-Salem, North Carolina. Kansas saw two deadly crashes over the weekend, The AP reported.

More than 2,300 flights were canceled and at least 9,100 more were delayed nationwide as of Monday night, according to tracking platform FlightAware. Ronald Reagan Washington National Airport reported that about 58% of arrivals and 70% of departures had been canceled.

A record 8 inches (more than 20 centimeters) of snow fell Sunday at the Cincinnati/Northern Kentucky International Airport, leading to dozens of flight cancellations that lingered into Monday. About 4 inches (about 10 centimeters) fell Monday across the Cincinnati area, where car and truck crashes shut at least two major routes leading into downtown.

More snow and ice are expected In Indiana, snow covered stretches of Interstate 64, Interstate 69 and U.S. Route 41, leading authorities to plead with people to stay home.

“It’s snowing so hard, the snow plows go through and then within a half hour the roadways are completely covered again,” State Police Sgt. Todd Ringle said.

The Mid-Atlantic region had been forecast to get another 6 to 12 inches (15 to 30 centimeters) of snow on Monday. Dangerously cold temperatures were expected to follow, with nighttime lows falling into the single digits (below minus 12.7 C) through the middle of the week across the Central Plains and into the Mississippi and Ohio valleys.

In North Texas, 2 to 5 inches (about 5 to 13 centimeters) of snow was expected beginning Thursday, according to the National Weather Service. Snow could also hit Oklahoma and Arkansas, with some parts potentially getting more than 4 inches (about 10 centimeters).

Classes canceled in several states School closings were widespread, with districts in Indiana, Virginia, Kentucky, Missouri and Kansas canceling or delaying the start of classes Monday. Among them was Kentucky’s Jefferson County Public Schools, which canceled classes and other school activities for its nearly 100,000 students.

Classes were also canceled in Maryland, where Gov. Wes Moore declared a state of emergency Sunday and announced that state government offices would also be closed Monday. Government offices also were closed Monday in Kentucky, where Gov. Andy Beshear declared a state of emergency.

Tens of thousands are without power Many were in the dark as temperatures plunged. More than 218,000 customers were without power Monday night across Kentucky, Indiana, Virginia, West Virginia, Illinois, Missouri and North Carolina, according to electric utility tracking website PowerOutage.us.

In Virginia’s capital city, a power outage caused a temporary malfunction in the water system, officials said Monday afternoon. Richmond officials asked those in the city of more than 200,000 people to refrain from drinking tap water or washing dishes without boiling the water first. The city also asked people to conserve their water, such as by taking shorter showers.

City officials said they were working nonstop to bring the system back online.