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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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Thieves Drill into a German Bank Vault and Steal Tens of Millions of Euros Worth of Property

Police officers stand in front of the savings bank branch in the Buer district in Gelsenkirchen, Germany, Tuesday, Dec. 30, 2025 following a break-in into the bank's vault. (Christoph Reichwein/dpa via AP)
Police officers stand in front of the savings bank branch in the Buer district in Gelsenkirchen, Germany, Tuesday, Dec. 30, 2025 following a break-in into the bank's vault. (Christoph Reichwein/dpa via AP)
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Thieves Drill into a German Bank Vault and Steal Tens of Millions of Euros Worth of Property

Police officers stand in front of the savings bank branch in the Buer district in Gelsenkirchen, Germany, Tuesday, Dec. 30, 2025 following a break-in into the bank's vault. (Christoph Reichwein/dpa via AP)
Police officers stand in front of the savings bank branch in the Buer district in Gelsenkirchen, Germany, Tuesday, Dec. 30, 2025 following a break-in into the bank's vault. (Christoph Reichwein/dpa via AP)

Thieves stole tens of millions of euros worth of property from safety deposit boxes inside a German bank vault that they drilled into Monday during the holiday lull, police said.

Some 2,700 bank customers were affected by the theft in Gelsenkirchen, police and the Sparkasse bank said.

Thomas Nowaczyk, a police spokesperson, said investigators believe the theft was worth between 10 and 90 million euros ($11.7 to 105.7 million).

German news agency dpa reported that the theft could be one of Germany's largest heists.

The bank remained closed Tuesday, when some 200 people showed up demanding to get inside, dpa reported.

A fire alarm summoned police officers and firefighters to the bank branch shortly before 4 a.m. Monday. They found a hole in the wall and the vault ransacked. Police believe a large drill was used to break through the vault's basement wall.

Witnesses told investigators they saw several men carrying large bags in a nearby parking garage over the weekend. Video footage from the garage shows masked people inside a stolen vehicle early Monday, police said.

Gelsenkirchen is about 192 kilometers (119 miles) northwest of Frankfurt.

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The Year's First Meteor Shower and Supermoon Clash in January Skies

People look up to the sky from an observatory near the village of Avren, Bulgaria, Aug. 12, 2009. (AP Photo/Petar Petrov, File)
People look up to the sky from an observatory near the village of Avren, Bulgaria, Aug. 12, 2009. (AP Photo/Petar Petrov, File)
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The Year's First Meteor Shower and Supermoon Clash in January Skies

People look up to the sky from an observatory near the village of Avren, Bulgaria, Aug. 12, 2009. (AP Photo/Petar Petrov, File)
People look up to the sky from an observatory near the village of Avren, Bulgaria, Aug. 12, 2009. (AP Photo/Petar Petrov, File)

The year's first supermoon and meteor shower will sync up in January skies, but the light from one may dim the other.

The Quadrantid meteor shower peaks Friday night into Saturday morning, according to the American Meteor Society. In dark skies during the peak, skygazers typically see around 25 meteors per hour, but this time they'll likely glimpse less than 10 per hour due to light from Saturday's supermoon, The AP news reported.

“The biggest enemy of enjoying a meteor shower is the full moon,” said Mike Shanahan, planetarium director at Liberty Science Center in New Jersey.

Meteor showers happen when speedy space rocks collide with Earth’s atmosphere, burning up and leaving fiery tails in their wake — the end of a “shooting star.” A handful of meteors are visible on any given night, but predictable showers appear annually when Earth passes through dense streams of cosmic debris.

Supermoons occur when a full moon is closer to Earth in its orbit. That makes it appear up to 14% bigger and 30% brighter than the faintest moon of the year, according to NASA. That difference can be tough to notice with the naked eye.

Supermoons, like all full moons, are visible in clear skies everywhere that it's night. The Quadrantids, on the other hand, can be seen mainly from the Northern Hemisphere. Both can be glimpsed without any special equipment.

To spot the Quadrantids, venture out in the early evening away from city lights and watch for fireballs before the moon crashes the party, said Jacque Benitez with the Morrison Planetarium at the California Academy of Sciences. Skygazers can also try looking during early dawn hours on Sunday.

Wait for your eyes to get used to the darkness, and don’t look at your phone. The space rocks will look like fast-moving white dots and appear over the whole sky.

Meteor showers are named for the constellation where the fireballs appear to come from. The Quadrantids — space debris from the asteroid 2003 EH1 — are named for a constellation that's no longer recognized.

The next major meteor shower, called the Lyrids, is slotted for April.

Supermoons happen a few times a year and come in groups, taking advantage of the sweet spot in the moon’s elliptical orbit. Saturday night’s event ends a four-month streak that started in October. There won't be another supermoon until the end of 2026.

Varieties

New Maritime Theater in Jazan to Host the City's Festival Opening

The site also includes various amenities, such as shopping zones, kiosks for dining, an art gallery - SPA
The site also includes various amenities, such as shopping zones, kiosks for dining, an art gallery - SPA
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New Maritime Theater in Jazan to Host the City's Festival Opening

The site also includes various amenities, such as shopping zones, kiosks for dining, an art gallery - SPA
The site also includes various amenities, such as shopping zones, kiosks for dining, an art gallery - SPA

The Jazan city theater on the southern corniche will host the opening ceremony of the Jazan Festival 2026 on Friday. This event will take place at a 35-square-kilometer site that features the Kingdom's largest maritime theater, SPA reported.

The theater accommodates more than 10,000 spectators and features five VIP areas. To ensure a smooth experience, the venue offers parking for over 9,000 vehicles, providing easy access during peak times.

Built specifically for the festival, the stage meets stringent safety and technical standards, providing a high-quality audiovisual experience against the stunning backdrop of the Red Sea.

The site also includes various amenities, such as shopping zones, kiosks for dining, an art gallery, a play area for children, a bird garden, and a regional museum, showcasing the region's history and culture.

This temporary maritime theater aims to provide a cohesive experience, integrating entertainment, culture, shopping, and services in one location, further establishing Jazan as a year-round destination for tourism and entertainment.