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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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Saudi Arabia Sets Guinness World Record with 95 Tons of Seasonal Seeds in Vegetation Cover Efforts

The achievement crowns a year of intensive efforts by the National Center for Vegetation Cover Development and Combating Desertification. (SPA)
The achievement crowns a year of intensive efforts by the National Center for Vegetation Cover Development and Combating Desertification. (SPA)
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Saudi Arabia Sets Guinness World Record with 95 Tons of Seasonal Seeds in Vegetation Cover Efforts

The achievement crowns a year of intensive efforts by the National Center for Vegetation Cover Development and Combating Desertification. (SPA)
The achievement crowns a year of intensive efforts by the National Center for Vegetation Cover Development and Combating Desertification. (SPA)

Saudi Arabia has reached a new global environmental milestone by earning a Guinness World Records title for the largest seasonal seed storage collection in the world, reflecting its ongoing commitment to environmental protection and sustainability, reported the Saudi Press Agency on Tuesday.

The achievement crowns a year of intensive efforts by the National Center for Vegetation Cover Development and Combating Desertification.

Over the course of the year, trained and specialized field teams traveled across the Kingdom to collect large quantities of native plant seeds in support of land rehabilitation projects and environmental sustainability initiatives.

The field teams successfully collected 31 species of local wild plants. The seeds underwent precise processing, including cleaning and purification to remove impurities and plant residues, before being stored according to the highest internationally recognized standards.

Seed warehouses housed more than 95 tons of rangeland and wild plant seeds, reinforcing the Kingdom’s leading role in environmental action and supporting the objectives of Saudi Vision 2030 related to natural resource protection and combating desertification.

The Kingdom has recorded numerous environmental milestones at the national, regional, and global levels as part of its broader efforts to promote sustainability in line with Saudi Vision 2030 and international goals to combat desertification and mitigate climate change.

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'Call of Duty' Co-creator Vince Zampella Killed in Car Crash

Vince Zampella died while driving his Ferrari north of Los Angeles. Frederick M. Brown / GETTY IMAGES NORTH AMERICA/AFP
Vince Zampella died while driving his Ferrari north of Los Angeles. Frederick M. Brown / GETTY IMAGES NORTH AMERICA/AFP
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'Call of Duty' Co-creator Vince Zampella Killed in Car Crash

Vince Zampella died while driving his Ferrari north of Los Angeles. Frederick M. Brown / GETTY IMAGES NORTH AMERICA/AFP
Vince Zampella died while driving his Ferrari north of Los Angeles. Frederick M. Brown / GETTY IMAGES NORTH AMERICA/AFP

Vince Zampella, the acclaimed co-creator of video gaming juggernaut "Call of Duty," has died in a car crash, gaming giant Electronic Arts confirmed on Monday. He was 55.

The developer and executive died on Sunday while driving his Ferrari on a scenic road north of Los Angeles, according to local broadcaster NBC4.

"For unknown reasons, the vehicle veered off the roadway, struck a concrete barrier, and became fully engulfed," the California Highway Patrol said in a statement, without identifying the two victims in the crash.

The CHP added that both the driver and a passenger who was ejected from the vehicle succumbed to their injuries, reported AFP.

Witnesses posted video of the mangled cherry-red Ferarri, engulfed in flames, on the mountain road. The cause of the crash remains under investigation.

His studios created some of the world's best-selling video games, and Zampella was considered an innovator in first-person military shooter style games.

This year, when his "Battlefield 6" video game set a new sales record for the franchise, Zampella expressed gratitude, saying "we never take moments like this for granted" -- despite a long career of success in gaming.

The mass-combat game has won over 100 million players in the past two decades, in its various iterations.

And yet, that number isn't a first. To this day, "Call of Duty" boasts more than 100 milion active players, monthly.

"You have that dream of the game being popular, but I don't think you're ever ready for that level of success," Zampella told gaming site IGN in a 2016 interview.

Profound, far-reaching

Zampella was best known for co-creating the "Call of Duty" franchise and founding Respawn Entertainment, the studio behind "Titanfall,Apex Legends," and the "Star Wars Jedi" games.

After starting out in the 1990s as a designer on shooter games, he co-founded Infinity Ward in 2002 and helped launch "Call of Duty" in 2003. Activision later acquired his studio.

He left Activision under contentious circumstances and established Respawn in 2010, which Electronic Arts acquired in 2017.

At EA, he eventually took charge of revitalizing the "Battlefield" franchise, cementing his reputation as one of the most influential figures in modern first-person shooter games.

"This is an unimaginable loss, and our hearts are with Vince's family, his loved ones, and all those touched by his work," Electronic Arts said in a statement.

"Vince's influence on the video game industry was profound and far-reaching," the company said, adding that "his work helped shape modern interactive entertainment."

A statement by Respawn, posted on the "Battlefield" X account, praised Zampella "for how he showed up every day, trusting his teams, encouraging bold ideas, and believing in Battlefield and the people building it."

Zampella "championed what he believed was right for the people behind those studios and our players because it mattered."

"It was a bold, transgressive method of storytelling, of a moment in time that was political, that was violent and that was impactful," Washington Post video game reporter Gene Park told NBC4.

"He really knew how to create stories and create experiences, that really hit at the heart of human experience -- whether it was terror, dread, heroism. I think he was really able to kindof encapsulate that through the designs of the video games that he made," Park said.

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GEA Chairman Named 2025 ‘Promoter of the Year’ by Boxing News

Turki Alalshikh, Chairman of the General Entertainment Authority (GEA) and Saudi Boxing Federation President, was named “Promoter of the Year” for 2025 by the Britain-based Boxing News magazine. (SPA)
Turki Alalshikh, Chairman of the General Entertainment Authority (GEA) and Saudi Boxing Federation President, was named “Promoter of the Year” for 2025 by the Britain-based Boxing News magazine. (SPA)
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GEA Chairman Named 2025 ‘Promoter of the Year’ by Boxing News

Turki Alalshikh, Chairman of the General Entertainment Authority (GEA) and Saudi Boxing Federation President, was named “Promoter of the Year” for 2025 by the Britain-based Boxing News magazine. (SPA)
Turki Alalshikh, Chairman of the General Entertainment Authority (GEA) and Saudi Boxing Federation President, was named “Promoter of the Year” for 2025 by the Britain-based Boxing News magazine. (SPA)

Turki Alalshikh, Chairman of the General Entertainment Authority (GEA) and Saudi Boxing Federation President, was named “Promoter of the Year” for 2025 by the Britain-based Boxing News magazine, the Saudi Press Agency reported on Tuesday.

The recognition reflects Alalshikh influential contributions and growing role in advancing the global boxing industry, built on a series of initiatives led by him in recent years.

It celebrates his efforts in elevating the stature of major fight cards, raising organizational standards, and enhancing both the sporting and media experience of boxing events, with a vision and strong international partnerships that have been instrumental in attracting the sport’s biggest global names.