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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
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AstraZeneca and Daiichi's Breast Cancer Drug Meets Goal in Study

FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo
FILE PHOTO: Test tubes are seen in front of a displayed AstraZeneca logo in this illustration taken, May 21, 2021. REUTERS/Dado Ruvic/Illustration/File Photo/File Photo

AstraZeneca said on Friday its experimental precision drug had slowed the progression of a common type of breast cancer in a late-stage trial, a boost for the company after its shares fell in July on results from a separate trial of the same drug for lung cancer.
The drug, datopotamab deruxtecan, which AstraZeneca is jointly developing with Japan's Daiichi Sankyo, is being closely watched by analysts and investors in part due to the promise of the class of drugs to which it belongs, known as antibody drug conjugates (ADC).
ADCs consist of tumor-seeking monoclonal antibodies that are combined with a cell-killing chemotherapy payload.
The trial data released on Friday showed the drug, abbreviated as Dato-DXd, demonstrated a statistically significant and clinically meaningful improvement in slowing the progression of a type of breast cancer in trial participants, compared to patients who received other treatments such as chemotherapy.
The trial focused on tumors that grow in response to the hormones estrogen or progesterone, which account for roughly two-thirds of breast cancer cases. The study participants' disease had spread to other parts of the body.
The British drugmaker also said that there was a "trend in improvement" in the other main goal of the study, "overall survival" of patients, but the data on that was not mature so the trial would continue as planned.
AstraZeneca shares rose 1.7% in early trading, to their highest level in more than five weeks.
AstraZeneca is simultaneously developing the drug for use in lung cancer, and while data from a separate late-stage trial released in July was positive, the market was concerned that the drug's benefits for use in lung cancer treatment might not as pronounced as hoped, leading shares to fall more than 6% on the day the data was released.
The company has not said when it will release detailed data from the lung cancer study.
Analysts see the positive results from the breast cancer trial as good for AstraZeneca, but the market is more focused on the results of a trial called MARIPOSA by Johnson & Johnson. It compares AstraZeneca’s blockbuster cancer drug Tagrisso alone with its own drug, Rybrevant, in combination with another medicine.
Those results are expected later this year.

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Sudan's Historic Acacia Forest Devastated as War Fuels Logging

Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
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Sudan's Historic Acacia Forest Devastated as War Fuels Logging

Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP
Little is left of the once sprawling acacia forest south of Sudan's capital. Ebrahim Hamid / AFP

Vast stretches of a once-verdant acacia forest south of Sudan's capital Khartoum have been reduced to little more than fields of stumps as nearly three years of conflict have fueled deforestation.

What was once a 1,500-hectare natural reserve has been "completely wiped out", Boushra Hamed, head of environmental affairs for Khartoum state, told AFP.

Al-Sunut forest had long served as a haven for migratory birds and a vital green shield against the Nile's seasonal floods.

"During the war, Khartoum state has lost 60 percent of its green cover," Hamed said, describing how century-old trees "were cut down with electric saws" for commercial timber and charcoal production.

Where tall acacias once cast cool shade over a wetland just upstream from the confluence of the Blue and White Nile, barren ground now lies exposed, criss-crossed by people gathering whatever wood remains.

Hamed called it "methodical destruction", though the perpetrators remain unknown and there has been no investigation.

Similar devastation is unfolding across several regions -- including western Darfur, neighboring Kordofan and the central states of Sennar and Al-Jazirah -- as insecurity and economic collapse drive unchecked logging, according to Sudan's Forests National Corporation.

According to a 2019 study by the Nairobi-based African Forest Forum, Sudan had already lost nearly half of its forested land since 1960 due to agricultural expansion, firewood collection and overgrazing.

By 2015, the country ranked among Africa's least forested nations, with around 10 percent of its territory still covered by woodland, the study said.

The report had also warned of further degradation if reforestation and sustainable management efforts were not implemented -- concerns now compounded by the ongoing conflict.

- 'Barrier' -

Aboubakr Al-Tayeb, who oversees Khartoum's forestry administration, said the damage "affects not only Khartoum, but Sudan and the wider African continent."

"The forest was home to several migratory species from Europe," he told AFP.

More than a hundred bird species, including ducks, geese, terns, ibis, herons, eagles and vultures, had been recorded in the area, alongside monkeys and small mammals.

Al-Nazir Ali Babiker, an agronomist, said the loss of tree cover could cause more severe seasonal flooding because the "forest acted as a barrier" against rising waters.

Flooding strikes Sudan every year, destroying homes, farmland and infrastructure and leaving many families with no choice but to flee to safer areas.

The war in Sudan, which erupted in April 2023, has already killed tens of thousands, displaced 11 million and shattered critical infrastructure.

Before the fighting, forests supplied roughly 70 percent of Sudan's energy consumption, primarily through charcoal and firewood, according to data from the African Forest Forum.

Al-Sunut had also been a popular leisure spot for Khartoum residents.

"We used to come in groups to study and have a good time," recalls Adam Hafiz Ibrahim, a student at Omdurman Islamic University.

Today, wood gatherers have supplanted the usual walkers. Disregarding army notices alerting them to landmines, men and women traverse the dry, open ground that now stands where the ancient forest once grew.

"We're not cutting the trees. We just pick up whatever wood's already on the ground to use for the fire," said Nafisa, a woman in her forties navigating the dry grasslands.

"We found the trees down. We collect the wood to sell to bakeries and families," said Mohamed Zakaria, a construction worker who lost his job because of the war.

Experts say that the economic hardship caused by the war combined with a lack of enforcement has encouraged logging.

"The logging continues, because those responsible for forest protection cannot access many areas," said Mousa el-Sofori, head of Sudan's Forests National Corporation.

Efforts to replant acacias are underway, Tayeb of the Khartoum forestry administration said, but seedlings grow slowly and can take years to mature.

Restoring the lost woodlands would be "long and costly", said Sofori.

"Some of these forests were centuries old," he added.

Varieties

Coffee Regions Hit by Extra Days of Extreme Heat, Say Scientists 

17 April 2012, North Rhine-Westphalia, Vluyn: A general view of Arabica Coffee beans. (dpa)
17 April 2012, North Rhine-Westphalia, Vluyn: A general view of Arabica Coffee beans. (dpa)
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Coffee Regions Hit by Extra Days of Extreme Heat, Say Scientists 

17 April 2012, North Rhine-Westphalia, Vluyn: A general view of Arabica Coffee beans. (dpa)
17 April 2012, North Rhine-Westphalia, Vluyn: A general view of Arabica Coffee beans. (dpa)

The world's main coffee-growing regions are roasting under additional days of climate change-driven heat every year, threatening harvests and contributing to higher prices, researchers said Wednesday.

An analysis found that there were 47 extra days of harmful heat per year on average in 25 countries representing nearly all global coffee production between 2021 and 2025, according to independent research group Climate Central.

Brazil, Vietnam, Colombia, Ethiopia and Indonesia -- which supply 75 percent of the world's coffee -- experienced on average 57 additional days of temperatures exceeding the threshold of 30C.

"Climate change is coming for our coffee. Nearly every major coffee-producing country is now experiencing more days of extreme heat that can harm coffee plants, reduce yields, and affect quality," said Kristina Dahl, Climate Central's vice president for science.

"In time, these impacts may ripple outward from farms to consumers, right into the quality and cost of your daily brew," Dahl said in a statement.

US tariffs on imports from Brazil, which supplies a third of coffee consumed in the United States, contributed to higher prices this past year, Climate Central said.

But extreme weather in the world's coffee-growing regions is "at least partly to blame" for the recent surge in prices, it added.

Coffee cultivation needs optimal temperatures and rainfall to thrive.

Temperatures above 30C are "extremely harmful" to arabica coffee plants and "suboptimal" for the robusta variety, Climate Central said. Those two plant species produce the majority of the global coffee supply.

For its analysis, Climate Central estimated how many days each year would have stayed below 30C in a world without carbon pollution but instead exceeded that level in reality -- revealing the number of hot days added by climate change.

The last three years have been the hottest on record, according to climate monitors.

Varieties

Dog Gives Olympics Organizers Paws for Thought

A dog wanders on the ski trail during the women's team cross country free sprint qualification event of the Milano Cortina 2026 Winter Olympic Games at Tesero Cross-Country Skiing Stadium in Lago di Tesero (Val di Fiemme), on February 18, 2026. (Photo by Anne-Christine POUJOULAT / AFP)
A dog wanders on the ski trail during the women's team cross country free sprint qualification event of the Milano Cortina 2026 Winter Olympic Games at Tesero Cross-Country Skiing Stadium in Lago di Tesero (Val di Fiemme), on February 18, 2026. (Photo by Anne-Christine POUJOULAT / AFP)
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Dog Gives Olympics Organizers Paws for Thought

A dog wanders on the ski trail during the women's team cross country free sprint qualification event of the Milano Cortina 2026 Winter Olympic Games at Tesero Cross-Country Skiing Stadium in Lago di Tesero (Val di Fiemme), on February 18, 2026. (Photo by Anne-Christine POUJOULAT / AFP)
A dog wanders on the ski trail during the women's team cross country free sprint qualification event of the Milano Cortina 2026 Winter Olympic Games at Tesero Cross-Country Skiing Stadium in Lago di Tesero (Val di Fiemme), on February 18, 2026. (Photo by Anne-Christine POUJOULAT / AFP)

A dog decided he would bid for an unlikely Olympic medal on Wednesday as he joined the women's cross country team free sprint in the Milan-Cortina Games.

The dog ran onto the piste in Tesero in northern Italy and gamely, even without skis, ran behind two of the competitors, Greece's Konstantina Charalampidou and Tena Hadzic of Croatia.

He crossed the finishing line, his moment of glory curtailed as he was collared by the organizers and led away -- his owner no doubt will have a bone to pick with him when they are reunited.