150-year-old Florida Keys Lighthouse Illuminated for 1st Time in a Decade

In this Friday, Oct. 6, 2023, photo provided by the Florida Keys News Bureau, boaters watch a sunset behind Alligator Reef Lighthouse off Islamorada, Fla., in the Florida Keys. (Andy Newman/Florida Keys News Bureau via AP)
In this Friday, Oct. 6, 2023, photo provided by the Florida Keys News Bureau, boaters watch a sunset behind Alligator Reef Lighthouse off Islamorada, Fla., in the Florida Keys. (Andy Newman/Florida Keys News Bureau via AP)
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150-year-old Florida Keys Lighthouse Illuminated for 1st Time in a Decade

In this Friday, Oct. 6, 2023, photo provided by the Florida Keys News Bureau, boaters watch a sunset behind Alligator Reef Lighthouse off Islamorada, Fla., in the Florida Keys. (Andy Newman/Florida Keys News Bureau via AP)
In this Friday, Oct. 6, 2023, photo provided by the Florida Keys News Bureau, boaters watch a sunset behind Alligator Reef Lighthouse off Islamorada, Fla., in the Florida Keys. (Andy Newman/Florida Keys News Bureau via AP)

A 150-year-old beacon that helped guide ships through the treacherous Florida Keys coral reefs before GPS, sonar and other technology made it obsolete is shining again as part of a national effort to save historic lighthouses that have dotted the US coast for more than a century.
An Islamorada community group that is spending $6 million to restore and preserve the Alligator Reef Lighthouse turned on its new solar-powered lights on Saturday to remind the public about the effort.
“Alligator Lighthouse was lit in 1873 and it stayed lit until about 2013, and then it went dark for 10 years,” said Rob Dixon, the executive director of Save Alligator Lighthouse, which took over the lighthouse's title in late 2021. “And now our Statue of Liberty is lit once again.”
The lighthouse is named after the USS Alligator, a Navy schooner that ran aground on the reef in 1822 and sank.
Alligator and five other aging lighthouses off the Keys were important maritime navigational aids that once warned ships away from the area's barrier coral reef. But modern-day satellite navigation made open-water lighthouses obsolete and such structures are being disposed of by the General Services Association.
A detailed engineering study of Alligator Lighthouse was completed to determine stabilization needs after many years in highly corrosive conditions, The Associated Press reported.
Dixon said an engineering study determined that it will take six years and $5 million to $6 million dollars to save the Alligator Lighthouse.
“There’s nobody in this community that doesn’t want to help our project,” he said.
Dixon said fundraising is well underway with about $500,000 already raised, including $215,000 from the Monroe County Tourist Development Council.



Scientists Produce Painstaking Wiring Diagram of a Mouse’s Brain

This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
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Scientists Produce Painstaking Wiring Diagram of a Mouse’s Brain

This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)
This image provided by the Allen Institute on April 8, 2025, shows a digital representation of neurons in a section of a mouse's brain, part of a project to create the largest map to date of brain wiring and function, in Seattle, Wash. (Forrest Collman/Allen Institute via AP)

Neuroscientists have produced the largest wiring diagram and functional map of a mammalian brain to date using tissue from a part of a mouse's cerebral cortex involved in vision, an achievement that could offer insight into how the human brain works.

They worked out the cerebral architecture in a tissue sample the size of a grain of sand bearing more than 200,000 cells including roughly 84,000 nerve cells, called neurons, and about 524 million connections between these neurons at junctions called synapses. In all, they collected data that covers about 3.4 miles (5.4 kilometers) of neuronal wiring in a part of the brain that processes visual information from the eyes.

"The millions of synapses and hundreds of thousands of cells come in such a diversity of shapes and sizes, and contain a massive complexity. Looking at their complexity gives, at least us, a sense of awe about the sheer complexity of our own minds," said neuroscientist Forrest Collman of the Allen Institute for Brain Science, one of the lead scientists in the research published on Wednesday in the journal Nature.

The cerebral cortex is the brain's outer layer, the main site of conscious perceptions, judgments and the planning and execution of movements.

"Scientists have been studying the structure and anatomy of the brain - including the morphology of different cell types and how they connect - for over a century. Simultaneously, they've been characterizing the function of neurons - for example, what information they process," said neuroscientist Andreas Tolias of Baylor College of Medicine, one of the research leaders.

"However, understanding how neuronal function emerges at the circuit level has been challenging, since we need to study both function and wiring in the same neurons. Our study represents the largest effort to date to systematically unify brain structure and function within a single individual mouse," Tolias added.

While there are notable differences between mouse and human brains, many organizational principles remain conserved across species.

The research focused upon a part of this region called the primary visual cortex, involved in the first stage of the brain's processing of visual information.

The research was conducted by the MICrONS, short for Machine Intelligence from Cortical Networks, a scientific consortium involving more than 150 scientists from various institutions.

Researchers at Baylor College of Medicine created a map of neural activity in a cubic millimeter of the primary visual cortex by recording brain cell responses while the laboratory mouse ran on a treadmill while watching a variety of video images, including from "The Matrix" films. The mouse had been genetically modified to make these cells emit a fluorescent substance when the neurons were active.

The same neurons were then imaged at the Allen Institute. Those images were assembled in three dimensions, and Princeton University researchers used artificial intelligence and machine learning to reconstruct the neurons and their connection patterns.

The brain is populated by a network of cells including neurons that are activated by sensory stimuli such as sight or sound or touch and are connected by synapses. Cognitive function involves the interplay between the activation of neurons and the connections among the brain cells.

The researchers see practical benefits from this type of research.

"First, understanding brain wiring rules can shed light on various neurological and psychiatric disorders, including autism and schizophrenia, which may arise from subtle wiring abnormalities. Second, knowing precisely how neuronal wiring shapes brain function allows us to uncover fundamental mechanisms of cognition," Tolias said.

One key finding highlighted in the research involved a map of how connections involving a broad class of neurons in the brain called inhibitory cells are organized. When these neurons become active, they make the cells to which they are connected less active. This stands in contrast to excitatory cells, which make the cells to which they connect more likely to become active. Inhibitory cells represent about 15% of the cortical neurons.

"We found many more highly specific patterns of inhibition than many, including us, were expecting to find," Collman said.

"Inhibitory cells don't just randomly connect to all the excitatory cells around them, but instead pick out very specific kinds of neurons to connect to. Further, it was known that there are four major kinds of inhibitory neurons in the cortex, but the patterns of specificity break up these categories into much finer groups," Collman said.