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India Announces Four-member Crew for Space Mission

FILE PHOTO: Intuitive Machines' Odysseus spacecraft passes over the near side of the Moon following lunar orbit insertion on February 21, 2024, in this handout image released February 22, 2024. Intuitive Machines/Handout via REUTERS
FILE PHOTO: Intuitive Machines' Odysseus spacecraft passes over the near side of the Moon following lunar orbit insertion on February 21, 2024, in this handout image released February 22, 2024. Intuitive Machines/Handout via REUTERS
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India Announces Four-member Crew for Space Mission

FILE PHOTO: Intuitive Machines' Odysseus spacecraft passes over the near side of the Moon following lunar orbit insertion on February 21, 2024, in this handout image released February 22, 2024. Intuitive Machines/Handout via REUTERS
FILE PHOTO: Intuitive Machines' Odysseus spacecraft passes over the near side of the Moon following lunar orbit insertion on February 21, 2024, in this handout image released February 22, 2024. Intuitive Machines/Handout via REUTERS

India on Tuesday introduced four crew members for its maiden 'Gaganyaan' space voyage, as it aims to become the world's fourth country to send a crewed mission into space just months after a historic landing on the south pole of the moon.
Gaganyaan, or "sky craft" in Hindi, is the first mission of its kind for India and will cost about 90.23 billion rupees ($1.1 billion). It involves the launch of a habitable space capsule over the next year to an orbit of 400 km (250 miles) and its return via a landing in the Indian Ocean.
Prime Minister Narendra Modi awarded the four crew members, all of them air force officers, "astronaut wings" at a space center in Thiruvananthapuram in Kerala state on Tuesday, in their first public appearance after months of rigorous training.
The four officers are Prashanth Balakrishnan Nair, Ajit Krishnan, Angad Pratap and Shubhanshu Shukla, a government statement said.
It was not clear if all four astronauts would be on board the mission, Reuters reported.
Gaganyaan is a "historic" achievement for India, Modi said on X and in a statement, coming four decades after air force officer, Rakesh Sharma, became the first Indian to travel to space - with a Soviet mission.
"Time is ours, countdown is ours and so is the rocket," Modi told space scientists.
Only the United States, Russia, and China have sent their own crewed missions into space.
Astronauts from more than three dozen other countries have made space trips aboard either US or Russian missions.

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Blood Tests Allow 30-year Estimates of Women's Cardio Risks, New Study Says

A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
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Blood Tests Allow 30-year Estimates of Women's Cardio Risks, New Study Says

A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights
A woman jogs in a park in Saint-Sebastien-sur-Loire near Nantes, France January 19, 2024. REUTERS/Stephane Mahe/File Photo Purchase Licensing Rights

Women’s heart disease risks and their need to start taking preventive medications should be evaluated when they are in their 30s rather than well after menopause as is now the practice, said researchers who published a study on Saturday.

Presenting the findings at the European Society of Cardiology annual meeting in London, they said the study showed for the first time that simple blood tests make it possible to estimate a woman’s risk of cardiovascular disease over the next three decades.

"This is good for patients first and foremost, but it is also important information for (manufacturers of) cholesterol lowering drugs, anti-inflammatory drugs, and lipoprotein(a)lowering drugs - the implications for therapy are broad," said study leader Dr. Paul Ridker of Brigham and Women’s Hospital in Boston, Reuters reported.

Current guidelines “suggest to physicians that women should generally not be considered for preventive therapies until their 60s and 70s. These new data... clearly demonstrate that our guidelines need to change,” Ridker said. “We must move beyond discussions of 5 or 10 year risk."

The 27,939 participants in the long-term Women’s Health Initiative study had blood tests between 1992 and 1995 for low density lipoprotein cholesterol (LDL-C or “bad cholesterol”), which are already a part of routine care.

They also had tests for high-sensitivity C-reactive protein (hsCRP) - a marker of blood vessel inflammation - and lipoprotein(a), a genetically determined type of fat.

Compared to risks in women with the lowest levels of each marker, risks for major cardiovascular events like heart attacks or strokes over the next 30 years were 36% higher in women with the highest levels of LDL-C, 70% higher in women with the highest levels of hsCRP, and 33% higher in those with the highest levels of lipoprotein(a).

Women in whom all three markers were in the highest range were 2.6 times more likely to have a major cardiovascular event and 3.7 times more likely to have a stroke over the next three decades, according to a report of the study in The New England Journal of Medicine published to coincide with the presentation at the meeting.

“The three biomarkers are fully independent of each other and tell us about different biologic issues each individual woman faces,” Ridker said.

“The therapies we might use in response to an elevation in each biomarker are markedly different, and physicians can now specifically target the individual person’s biologic problem.”

While drugs that lower LDL-C and hsCRP are widely available - including statins and certain pills for high blood pressure and heart failure - drugs that reduce lipoprotein(a) levels are still in development by companies, including Novartis , Amgen , Eli Lilly and London-based Silence Therapeutics.

In some cases, lifestyle changes such as exercising and quitting smoking can be helpful.

Most of the women in the study were white Americans, but the findings would likely “have even greater impact among Black and Hispanic women for whom there is even a higher prevalence of undetected and untreated inflammation,” Ridker said.

“This is a global problem,” he added. “We need universal screening for hsCRP ... and for lipoprotein(a), just as we already have universal screening for cholesterol.”