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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP
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Axsome's Alzheimer's-related Drug Shows Mixed Results in Late-stage Studies

The human brain. Illustration: AFP
The human brain. Illustration: AFP

Axsome Therapeutics said on Monday its experimental drug to treat agitation related to Alzheimer's disease succeeded in one of the two late-stage studies and failed to meet the main goal of the second trial.

Shares of the drug developer, which was testing the treatment, AXS-05, dropped 12% in premarket trading, Reuters reported.

The agitation is a symptom that causes emotional distress as well as verbal and physical aggressiveness.

The treatment significantly delayed the time to relapse in agitation as measured on a disease severity scale in one study, but did not demonstrate statistical significance in delaying agitation in another late-stage trial.

AXS-05 was safe and well tolerated in both the studies, the company said.

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Australian Hiker Found Alive after Surviving for Two Weeks on Berries and Muesli Bars

A general view of Cooma Hospital where hiker Hadi Nazari was transferred to for a health check in Cooma, New South Wales, Australia, 08 January 2025. (EPA)
A general view of Cooma Hospital where hiker Hadi Nazari was transferred to for a health check in Cooma, New South Wales, Australia, 08 January 2025. (EPA)
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Australian Hiker Found Alive after Surviving for Two Weeks on Berries and Muesli Bars

A general view of Cooma Hospital where hiker Hadi Nazari was transferred to for a health check in Cooma, New South Wales, Australia, 08 January 2025. (EPA)
A general view of Cooma Hospital where hiker Hadi Nazari was transferred to for a health check in Cooma, New South Wales, Australia, 08 January 2025. (EPA)

An Australian student missing for two weeks near the country's tallest mountain was found on Wednesday, after surviving by foraging for berries, drinking water from a creek and finding two muesli bars left behind by other hikers, police said.

Hadi Nazari, a 23-year-old university student from Melbourne, went missing from his group of friends on December 26 in the Kosciuszko National Park.

Nazari was found on Wednesday afternoon by a group of hikers who alerted the authorities, police in the state of New South Wales said.

“This is the fourteenth day we've been looking for him and for him to come out and be in such good spirits and in such great condition, it’s incredible," NSW Police Inspector Josh Broadfoot said.

The student was in "really good spirits" with no significant injuries, he added.

More than 300 people had searched for Nazari across rugged bushland, police said. The national park is home to the 2,228 meter (7,310 foot) Mount Kosciuszko.