Iran’s Supreme Leader Rejects Direct Nuclear Talks with US as European Negotiations Remain Unmoved 

Iranians walk next to Iran's national flags in Tehran, Iran, 20 September 2025. (EPA)
Iranians walk next to Iran's national flags in Tehran, Iran, 20 September 2025. (EPA)
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Iran’s Supreme Leader Rejects Direct Nuclear Talks with US as European Negotiations Remain Unmoved 

Iranians walk next to Iran's national flags in Tehran, Iran, 20 September 2025. (EPA)
Iranians walk next to Iran's national flags in Tehran, Iran, 20 September 2025. (EPA)

Iran's supreme leader on Tuesday rejected direct negotiations with the United States over his country's nuclear program, likely slamming the door shut on a last-ditch effort to halt the reimposition of United Nations sanctions on Tehran. 

Ali Khamenei's remarks, aired on Iranian state television, likely constrain any possible outreach to the US by Iranian President Masoud Pezeshkian, who is in New York for the UN General Assembly. Separately, Iranian Foreign Minister Abbas Araghchi held meetings there with diplomats from France, Germany and Britain over the reimposition of the sanctions, set to take effect Sunday. 

Talks with the US represent "a sheer dead end," Khamenei said. 

"The US has announced the results of the talks in advance," he added. "The result is the closure of nuclear activities and enrichment. This is not a negotiation. It is a diktat, an imposition." 

The German Foreign Office, in comments posted on X after the meeting with Araghchi, said that France, Germany, Britain and the EU urged Iran to take steps within days, "if not hours," to address concerns over its nuclear program. It should resume direct talks with the US and provide the International Atomic Energy Agency with access to all its nuclear sites, "in line with its obligations," the statement said. 

The three European countries, known as the E3, triggered the so-called "snapback" mechanism to reinstate sanctions — barring a last-minute accord — over Iran's failure to comply with conditions of a 2015 nuclear deal aimed at preventing Tehran from developing nuclear weapons. 

The meeting Tuesday did not appear to move closer to a resolution before Saturday’s deadline. But a French diplomat said that the European leaders plan to make "full use" of the remaining time. The diplomat spoke on condition of anonymity because they were not authorized to publicly discuss the private meeting. 

The German Foreign Office said "diplomatic engagement" would continue even if sanctions are reimposed Sunday. 

Earlier, Germany’s Foreign Minister Johann Wadephul had described the chance of reaching an agreement with Iran by the weekend "extremely slim," the German news agency dpa had reported, even before Khamenei’s comments. 

In his speech late Tuesday, French President Emmanuel Macron said the Middle East region can only be at peace if Iran’s nuclear program "is once again fully under control." 

"The next steps to come will be decisive," he said, adding that he’s willing to meet with Iran’s president this week to secure a deal. 

Iran has stopped inspectors, refused US talks  

Amid a flurry of diplomatic engagements, Araghchi on Monday also met with Rafael Grossi, the International Atomic Energy Agency (IAEA) director-general, in New York. 

Earlier this month, the UN nuclear watchdog and Iran signed an agreement mediated by Egypt to pave the way for resuming cooperation, including on ways of relaunching inspections of Iran’s nuclear facilities. However, that agreement has yet to fully take hold. 

In July, Pezeshkian signed a law adopted by his country’s parliament suspending all cooperation with the UN nuclear watchdog. That followed Israel’s 12-day war with Iran in June, during which Israel and the US bombed Iranian nuclear sites. 

France, Germany and the UK began the process of reimposing sanctions on Iran at the end of August. 

The process — termed a "snapback" by the diplomats who negotiated it into Iran’s 2015 nuclear deal with world powers — was designed to be veto-proof at the UN. It started a 30-day clock ticking for the resumption of sanctions unless the West and Iran reach a diplomatic agreement. 

European nations have said they would be willing to extend the deadline if Iran resumes direct negotiations with the US over its nuclear program, allows UN nuclear inspectors access to its nuclear sites, and accounts for the more than 400 kilograms (880 pounds) of highly enriched uranium the UN watchdog says it has. Iran is the only nation in the world that enriches uranium up to 60%, a short, technical step from weapons-grade levels, that does not have a weapons program. 

If no diplomatic deal is found this week, the sanctions will automatically "snapback" on Sunday. That would again freeze Iranian assets abroad, halt arms deals with Tehran and penalize any development of Iran’s ballistic missile program, among other measures, further squeezing the country’s reeling economy. 

Khamenei made a point in his roughly half-hour speech to say his comments focused only on America, not on Europe. 

Iran maintains its atomic program is peaceful Iran has long insisted its program is peaceful, though Western nations and the IAEA assess that Tehran had an active nuclear weapons program until 2003. Khamenei again pledged that Iran does not seek atomic bombs. 

"We do not have a nuclear bomb and we will not have one, and we do not plan to use nuclear weapon," he said. 

US President Donald Trump, who unilaterally withdrew America from the Iran nuclear deal in 2018, made a point to reference Tehran in his speech before the UN on Tuesday. He recounted writing a letter to Khamenei seeking talks. US and Iranian negotiators met five times before the 12-day war in June. 

"There is no more serious danger to our planet today than the most powerful and destructive weapons ever devised by man, of which the United States, as you know, has many," Trump said. "I’ve made containing these threats a top priority, starting with (the) nation of Iran." 

However, Khamenei stressed that Israeli and American attacks would not destroy the nuclear knowledge gained by Iran over the decades over the crisis surrounding the program. 

"Science will not be demolished by threats and bombing," he vowed. 



US, Israel Unlikely to Achieve ‘Regime Change’ in Iran, Says Merz

 27 March 2026, Hesse, Frankfurt/Main: Germany's Chancellor Friedrich Merz speaks at the "FAZ" Congress. (dpa)
27 March 2026, Hesse, Frankfurt/Main: Germany's Chancellor Friedrich Merz speaks at the "FAZ" Congress. (dpa)
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US, Israel Unlikely to Achieve ‘Regime Change’ in Iran, Says Merz

 27 March 2026, Hesse, Frankfurt/Main: Germany's Chancellor Friedrich Merz speaks at the "FAZ" Congress. (dpa)
27 March 2026, Hesse, Frankfurt/Main: Germany's Chancellor Friedrich Merz speaks at the "FAZ" Congress. (dpa)

The US-Israeli war against Iran is unlikely to lead to "regime change", German Chancellor Friedrich Merz said Friday, as the month-long conflict showed no signs of abating.

"Is regime change really the goal?" he said at a forum in Frankfurt organized by the FAZ newspaper.

"If that's the goal, I don't think you'll achieve it. It's mostly gone wrong" in past conflicts, he said, pointing to the Afghanistan war.

"I have serious doubts as to whether there is a strategy and whether that strategy is being successfully implemented," he added. "In that respect, it could take even longer."

Germany has pushed back at US President Donald Trump's criticisms of NATO members for failing to join the attacks on Iran, insisting that it is not their war.

Merz however said Friday he believed that Trump had accepted this stance.

He also said Germany would be open to helping provide military protection in the Strait of Hormuz, a key route for oil and gas, which has been nearly totally blocked, in the event of a ceasefire.

"This requires an international mandate, it requires approval from the German parliament and, prior to that, a cabinet decision. And we are far from that."


More Than 300 US Troops Injured Since Start of Iran War

US Navy sailors taxi an F/A-18F Super Hornet on the flight deck aboard Nimitz-class aircraft carrier USS Abraham Lincoln in support of the Operation Epic Fury attack on Iran from an undisclosed location March 17, 2026. (US Navy/Handout via Reuters)
US Navy sailors taxi an F/A-18F Super Hornet on the flight deck aboard Nimitz-class aircraft carrier USS Abraham Lincoln in support of the Operation Epic Fury attack on Iran from an undisclosed location March 17, 2026. (US Navy/Handout via Reuters)
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More Than 300 US Troops Injured Since Start of Iran War

US Navy sailors taxi an F/A-18F Super Hornet on the flight deck aboard Nimitz-class aircraft carrier USS Abraham Lincoln in support of the Operation Epic Fury attack on Iran from an undisclosed location March 17, 2026. (US Navy/Handout via Reuters)
US Navy sailors taxi an F/A-18F Super Hornet on the flight deck aboard Nimitz-class aircraft carrier USS Abraham Lincoln in support of the Operation Epic Fury attack on Iran from an undisclosed location March 17, 2026. (US Navy/Handout via Reuters)

More than 300 US troops have been wounded since the start of the Iran war on February 28, US Central Command said on Friday.

"Since the start of Operation Epic Fury, approximately 303 US service members have been wounded. The vast majority of these injuries have been minor, and 273 troops have returned to duty," US Navy Captain Tim Hawkins said.

A US official who asked not to be identified told AFP that 10 troops remain seriously wounded.

A further 13 troops have been killed in the war, according to the latest figures, with seven killed in the Gulf and six in Iraq.

In a separate development Friday, Iran's military said that hotels housing US soldiers in the region would be considered targets.

"When all the Americans (forces) go into a hotel, then from our perspective that hotel becomes American," armed forces spokesman Abolfazl Shekarchi told state television on Thursday.

Iran's government has not released an updated casualty toll, but a US-based activist group said on March 23 that some 1,167 Iranian troops had been killed and 658 troops' status is unknown. AFP is not able to independently verify tolls in Iran due to reporting restrictions.

The war began on February 28 when the United States and Israel launched strikes on Iran, killing its supreme leader Ali Khamenei.

Since then, the conflict has spread across the Middle East. Iran has fired drone and missiles at Gulf states home to American military bases and other interests.

US President Donald Trump insisted on Thursday that talks to end the conflict were "ongoing" and "going very well".


UN Appeals for $80 Mn for Refugees, Hosts in Iran

 A man clears debris from a building damaged after a nearby residential building was hit in a US-Israeli strike in Tehran, Friday, March 27, 2026. (AP)
A man clears debris from a building damaged after a nearby residential building was hit in a US-Israeli strike in Tehran, Friday, March 27, 2026. (AP)
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UN Appeals for $80 Mn for Refugees, Hosts in Iran

 A man clears debris from a building damaged after a nearby residential building was hit in a US-Israeli strike in Tehran, Friday, March 27, 2026. (AP)
A man clears debris from a building damaged after a nearby residential building was hit in a US-Israeli strike in Tehran, Friday, March 27, 2026. (AP)

The United Nations said Friday it had launched an $80-million appeal to address the urgent humanitarian needs of nearly two million refugees in Iran and their host communities as the Middle East war rages.

Iran hosts the largest number of refugees in the world and has a significant migrant population, including 4.5 million Afghans, according to Tehran, and, according to the UN, hundreds of thousands of Iraqis.

"With the recent escalation of conflict, refugees, other Afghans and host communities in Iran are struggling with concerns for their safety, job losses, psychological distress and urgent shelter needs," said Babar Baloch, spokesman for UNHCR, the UN refugee agency.

UNHCR and its humanitarian partners have put together a flash refugee response plan, urgently seeking $80 million to respond to the immediate humanitarian needs from March to May.

"This will cover 1.8 million Afghan refugees and Afghans under other status living in Iran, plus also a million in their hosting communities who have also been affected," Baloch told a press conference.

"In Iran, most Afghan refugees, they live with the urban communities side by side, and everyone is affected," he said, adding that UNHCR was getting "thousands of desperate calls every day" from Afghans seeking support.

The Middle East war erupted on February 28 when Washington and Israel launched strikes on Iran, with Tehran in turn attacking targets in Israel and Gulf nations.

The UN's International Organization for Migration said no atypical outflows of people from Iran had been detected.

Meanwhile, the International Committee of the Red Cross said the month of war had upended the lives of millions and sent shockwaves far beyond the region at a speed "that threatens to overwhelm the humanitarian response".

"Essential infrastructure critical for the supply of energy, water and health care has been damaged or destroyed. The use of heavy explosive weapons with wide area impact in urban settings has caused suffering and fear," the ICRC said in a statement.

"Without respect for the rules of war, civilians will continue to suffer profound consequences that could outlast the current conflict."