Overdosing on Ibuprofen Causes Stomach Bleeding

Overdosing on Ibuprofen Causes Stomach Bleeding
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Overdosing on Ibuprofen Causes Stomach Bleeding

Overdosing on Ibuprofen Causes Stomach Bleeding

Many adults who use ibuprofen and other so-called nonsteroidal anti-inflammatory (NSAID) drugs take too much, increasing their risk of serious side effects like internal bleeding and heart attacks, a US study suggests.

About 15 percent of adults taking ibuprofen (Motrin, Advil) or other NSAIDs like aspirin, naproxen (Aleve), celecoxib (Celebrex), meloxicam (Mobic) and diclofenac (Voltaren) exceeded the maximum recommended daily dose for these drugs, the study found.

“NSAIDs are among the most commonly used medicines in the U.S. and worldwide,” said lead study author Dr. David Kaufman of Boston University.

“These drugs can have serious side effects, including gastrointestinal bleeding and heart attacks, and are often taken without medical oversight because many products are available over-the-counter,” Kaufman said by email. “The attitude that users can choose their own dose regardless of label directions, along with poor knowledge of dosing limits, is associated with exceeding the daily limit.”

For the study, 1,326 people who reported taking ibuprofen in the previous month completed online medication diaries every day for one week.

All of the participants took ibuprofen during the diary week, and 87 percent of them only used over-the-counter, or nonprescription, versions, researchers report in Pharmacoepidemiology & Drug Safety.

Overall, 55 percent of participants took ibuprofen at least three days during the week, and 16 percent took it every day.

In addition to ibuprofen, 37 percent of the participants reported taking at least one other NSAID during the week, most often aspirin or naproxen. Less than half of them recognized that all of the products they were taking were NSAIDs.

One limitation of the study is that researchers only focused on recent and current ibuprofen users, which may not reflect what doses might be typical for sporadic or new users, the authors note.

Even so, the findings highlight a potential downside of making NSAIDs widely available without a prescription, said Dr. Gunnar Gislason, director of research for the Danish Heart Foundation in Copenhagen.

“I believe that the message sent to the consumer when these drugs are widely available in convenience stores and gas stations is that these drugs are safe and you can use them safely for pain relief - thus no need for reading the label,” Gislason, who wasn’t involved in the study, said by email.

Even when people do read the label, they may still ignore it.

“If the recommended dosage does not give sufficient pain relief, it is easier to take more pills than seeking professional advice from a healthcare person or doctor,” Gislason added.

While doctors may prescribe NSAIDs for some muscle and joint disorders and certain other health problems, these drugs aren’t appropriate for many of the reasons that patients may buy them at the drugstore, said Dr. Liffert Vogt of the Academic Medical Center at the University of Amsterdam in the Netherlands.

“In my opinion NSAIDs should not be available as an over-the-counter drug, because of all their deleterious effects,” Vogt, who wasn’t involved in the study, said by email.

“For occasional use, acetaminophen (again in the right dose) is a much safer option and very efficacious as a painkiller,” Vogt added. “But we know that many people use NSAIDs for indications other than pain, such as flu, allergies, fever - and there is no medical base that indicates that NSAIDs or acetaminophen are of any use under these circumstances.”



Year after Exodus, Silence Fills Panama Island Threatened by Sea

The evacuation of around 1,200 members of the Indigenous Guna community to a new life on the mainland was one of the first planned migrations in Latin America due to climate change. MARTIN BERNETTI / AFP
The evacuation of around 1,200 members of the Indigenous Guna community to a new life on the mainland was one of the first planned migrations in Latin America due to climate change. MARTIN BERNETTI / AFP
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Year after Exodus, Silence Fills Panama Island Threatened by Sea

The evacuation of around 1,200 members of the Indigenous Guna community to a new life on the mainland was one of the first planned migrations in Latin America due to climate change. MARTIN BERNETTI / AFP
The evacuation of around 1,200 members of the Indigenous Guna community to a new life on the mainland was one of the first planned migrations in Latin America due to climate change. MARTIN BERNETTI / AFP

Streets once filled with children's laughter have fallen silent on a Panamanian island where almost all residents left a year ago due to the threat of the sea swallowing their homes.

The evacuation of around 1,200 members of the Indigenous Guna community to a new life on the mainland was one of the first planned migrations in Latin America due to climate change.

The exodus from Gardi Sugdub in the Caribbean left those who remained with a sense of sadness, said Delfino Davies, who has a small museum on the island with spears, jars and animal bones.

"There are no friends left or children playing," he told AFP.

Gardi Sugdub now has the silence of a "dead island," he said.

Dusty desks and empty classrooms are all that remain of a school that once bustled with children.

Many of the island's wooden houses are padlocked.

"There's no one here. Sometimes I get sad when I'm here alone," Mayka Tejada, 47, said in the small store where she sells bananas, pumpkins, clothes, toys and notebooks.

Like Davies and about 100 others, she decided to stay.

But her mother and two children, aged 16 and 22, moved to one of the 300 houses built by the Panamanian government in a new neighborhood called Isber Yala on the mainland, a 15-minute boat ride away.

Gardi Sugdub, the size of around five football fields, is one of 49 inhabited islands in the Guna Yala archipelago -- also known as San Blas -- which scientists warn is in danger of disappearing by the end of the century.

'I'll die here'

Sitting in a hammock in her earthen-floor house filled with the aroma of medicinal herbs, 62-year-old Luciana Perez said she had no intention of leaving.

"I was born in Gardi and I'll die here. Nothing is sinking. Scientists don't know, only God," she said.

Perez said that she was not afraid because since she was a child she had seen big waves and rising waters flooding houses at times.

Steven Paton, a scientist at the Panama-based Smithsonian Tropical Research Institute, said climate change meant that sea levels were expected to rise by up to 80 centimeters.

"Most of the Guna Yala islands are about 50 centimeters above sea level," he told AFP. "They'll be underwater."

Ana Toni, CEO of the United Nations' COP30 climate conference, told AFP that the mass evacuation "shows the reality we already have to face on the planet."

Sidewalks, water, electricity

The arrival of the rainy season has left puddles dotting the dirt roads of Gardi Sugdub.

In contrast, in the new settlement of Isber Yala -- "land of loquats" in the Guna language -- the streets are paved and have sidewalks.

The nearly 50-square-meter (500-square-feet) concrete houses have flushing toilets and there is a plot of land to grow vegetables.

On Gardi Sugdub "we lived crowded together, and I had to go fetch water from the river in a small boat," said Magdalena Martinez, a 75-year-old retired teacher.

In Isber Yala, water is available for an hour in the morning, she said.

"I can fill the buckets. And I have electricity 24 hours a day," said Martinez, who lives with her granddaughter in the new neighborhood.

Tejada's children also have no regrets about leaving the island, she said.

"I miss them, but they're happy there. They have a place to play football and walk around," Tejada said.

While the island's school relocated to Isber Yala, its dilapidated clinic remained in Gardi Sugdub.

"Before, people came on foot. Now, they have to travel by land and sea to get here. There are fewer visitors," said 46-year-old doctor John Smith.

Some of the islanders divide their time between the two communities, while others visit occasionally to check on their homes.

This week, there will be more activity than normal: seven jars of chicha -- a fermented corn drink -- are ready for Isber Yala's first anniversary.

Martinez is looking forward to the celebration, even though it will be bittersweet.

Although she may not see it herself, "the islands will disappear because the sea will reclaim its territory," she said.