What to Know about the Tensions between Iran and the US before Their Third Round of Talks

The flags of US and Iran are displayed in Muscat, Oman, 25 April 2025. Iran and US will hold third round of nuclear talks on 26 April 2025, in Muscat. (EPA)
The flags of US and Iran are displayed in Muscat, Oman, 25 April 2025. Iran and US will hold third round of nuclear talks on 26 April 2025, in Muscat. (EPA)
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What to Know about the Tensions between Iran and the US before Their Third Round of Talks

The flags of US and Iran are displayed in Muscat, Oman, 25 April 2025. Iran and US will hold third round of nuclear talks on 26 April 2025, in Muscat. (EPA)
The flags of US and Iran are displayed in Muscat, Oman, 25 April 2025. Iran and US will hold third round of nuclear talks on 26 April 2025, in Muscat. (EPA)

Iran and the United States will hold talks Saturday in Oman, their third round of negotiations over Tehran’s rapidly advancing nuclear program.

The talks follow a first round held in Muscat, Oman, where the two sides spoke face to face. They then met again in Rome last weekend before this scheduled meeting again in Muscat.

Trump has imposed new sanctions on Iran as part of his “maximum pressure” campaign targeting the country. He has repeatedly suggested military action against Iran remained a possibility, while emphasizing he still believed a new deal could be reached by writing a letter to Iran’s 85-year-old Supreme Leader Ali Khamenei to jumpstart these talks.

Khamenei has warned Iran would respond to any attack with an attack of its own.

Here’s what to know about the letter, Iran’s nuclear program and the tensions that have stalked relations between Tehran and Washington since the 1979 revolution.

Why did Trump write the letter? Trump dispatched the letter to Khamenei on March 5, then gave a television interview the next day in which he acknowledged sending it. He said: “I’ve written them a letter saying, ‘I hope you’re going to negotiate because if we have to go in militarily, it’s going to be a terrible thing.’”

Since returning to the White House, the president has been pushing for talks while ratcheting up sanctions and suggesting a military strike by Israel or the US could target Iranian nuclear sites.

A previous letter from Trump during his first term drew an angry retort from the supreme leader.

But Trump’s letters to North Korean leader Kim Jong Un in his first term led to face-to-face meetings, though no deals to limit Pyongyang’s atomic bombs and a missile program capable of reaching the continental US.

How did the first round go? Oman, a sultanate on the eastern edge of the Arabian Peninsula, hosted the first round of talks between Iranian Foreign Minister Abbas Araghchi and US Middle East envoy Steve Witkoff. The two men met face to face after indirect talks and immediately agreed to this second round in Rome.

Witkoff later made a television appearance in which he suggested 3.67% enrichment for Iran could be something the countries could agree on. But that’s exactly the terms set by the 2015 nuclear deal struck under US President Barack Obama, from which Trump unilaterally withdrew America.

Witkoff hours later issued a statement underlining something: “A deal with Iran will only be completed if it is a Trump deal.” Araghchi and Iranian officials have latched onto Witkoff’s comments in recent days as a sign that America was sending it mixed signals about the negotiations.

Yet the Rome talks ended up with the two sides agreeing to starting expert-level talks this Saturday. Analysts described that as a positive sign, though much likely remains to be agreed before reaching a tentative deal.

Why does Iran’s nuclear program worry the West? Iran has insisted for decades that its nuclear program is peaceful. However, its officials increasingly threaten to pursue a nuclear weapon. Iran now enriches uranium to near weapons-grade levels of 60%, the only country in the world without a nuclear weapons program to do so.

Under the original 2015 nuclear deal, Iran was allowed to enrich uranium up to 3.67% purity and to maintain a uranium stockpile of 300 kilograms (661 pounds). The last report by the International Atomic Energy Agency on Iran’s program put its stockpile at 8,294.4 kilograms (18,286 pounds) as it enriches a fraction of it to 60% purity.

US intelligence agencies assess that Iran has yet to begin a weapons program, but has “undertaken activities that better position it to produce a nuclear device, if it chooses to do so.”

Ali Larijani, an adviser to Iran’s supreme leader, has warned in a televised interview that his country has the capability to build nuclear weapons, but it is not pursuing it and has no problem with the International Atomic Energy Agency’s inspections. However, he said if the US or Israel were to attack Iran over the issue, the country would have no choice but to move toward nuclear weapon development.

“If you make a mistake regarding Iran’s nuclear issue, you will force Iran to take that path, because it must defend itself,” he said.

Why are relations so bad between Iran and the US? Iran was once one of the US’s top allies in the Middle East under Shah Mohammad Reza Pahlavi, who purchased American military weapons and allowed CIA technicians to run secret listening posts monitoring the neighboring Soviet Union. The CIA had fomented a 1953 coup that cemented the shah’s rule.

But in January 1979, the shah, fatally ill with cancer, fled Iran as mass demonstrations swelled against his rule. The revolution followed, led by Khomeini, and created Iran’s theocratic government.

Later that year, university students overran the US Embassy in Tehran, seeking the shah’s extradition and sparking the 444-day hostage crisis that saw diplomatic relations between Iran and the US severed. The Iran-Iraq war of the 1980s saw the US back Saddam Hussein. The “Tanker War” during that conflict saw the US launch a one-day assault that crippled Iran at sea, while the US later shot down an Iranian commercial airliner that the American military said it mistook for a warplane.

Iran and the US have see-sawed between enmity and grudging diplomacy in the years since, with relations peaking when Tehran made the 2015 nuclear deal with world powers. But Trump unilaterally withdrew America from the accord in 2018, sparking tensions in the Middle East that persist today.



A Son of Iran’s Late Supreme Leader Is a Possible Candidate to Replace His Father as War Rages

Mojtaba Khamenei, the son of Iranian Supreme Leader Ali Khamenei, center, attends the annual Quds, or Jerusalem Day rally in Tehran, Iran, on May 31, 2019. (AP)
Mojtaba Khamenei, the son of Iranian Supreme Leader Ali Khamenei, center, attends the annual Quds, or Jerusalem Day rally in Tehran, Iran, on May 31, 2019. (AP)
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A Son of Iran’s Late Supreme Leader Is a Possible Candidate to Replace His Father as War Rages

Mojtaba Khamenei, the son of Iranian Supreme Leader Ali Khamenei, center, attends the annual Quds, or Jerusalem Day rally in Tehran, Iran, on May 31, 2019. (AP)
Mojtaba Khamenei, the son of Iranian Supreme Leader Ali Khamenei, center, attends the annual Quds, or Jerusalem Day rally in Tehran, Iran, on May 31, 2019. (AP)

Mojtaba Khamenei, a son of Iran's late Supreme Leader Ali Khamenei has long been considered a contender to the post of the country's next paramount ruler — even before an Israeli strike killed his father at the start of the war last week and despite the fact he's has never been elected or appointed to a government position.

A secretive figure within the Islamic Republic, Mojtaba Khamenei has not been seen publicly since Saturday, when the Israeli airstrike targeting the supreme leader's offices killed his 86-year-old father. Also killed were the younger Khamenei's wife, Zahra Haddad Adel, who came from a family long associated with the country's theocracy.

Khamenei is believed to still be alive and has likely has gone into hiding as American and Israeli airstrikes continue to pound Iran, though state-run Iranian media have not reported on his whereabouts.

Profile of Khamenei's son rises after airstrike

Mojtaba Khamenei's name continues to circulate as a possible candidate to replace his father, something that had been criticized in the past as potentially creating a theocratic version of Iran's former hereditary monarchy.

But now with his father and wife considered by hard-liners as martyrs in the war against America and Israel, Khamenei's stock likely has risen with the aging clerics of the 88-seat Assembly of Experts who will select the country's next supreme leader.

Whoever becomes the leader will gain control of an Iranian military now at war and a stockpile of highly enriched uranium that could be used to build a nuclear weapon — should he choose to decree it.

Khamenei had occupied a similar role to that of Ahmad Khomeini, a son of Iran's first Supreme Leader Khomeini — "a combination of aide-de-camp, confidant, gatekeeper and power broker,” according to United Against Nuclear Iran, a US-based pressure group.

Born into dissent

Born in 1969 in the city of Mashhad, some 10 years before the 1979 revolution that would sweep Iran, Khamenei grew up as his father agitated against Shah Mohammad Reza Pahlavi of Iran.

An official biography on Ali Khamenei's life recounts one moment when the shah's secret police, the SAVAK, broke into their home and beat the cleric. Woken up after, Mojtaba and the rest of Khamenei's children were told their father was going on vacation.

“But I told them, ‘There is no need to lie.’ I told them the truth,” the elder Khamenei was quoted as saying.

After the fall of the shah, Khamenei's family moved to Tehran, Iran's capital. Khamenei would go on to fight in the Iran-Iraq war with the Habib ibn Mazahir Battalion, a division of Iran's paramilitary Revolutionary Guard that would see several of its members ascend to powerful intelligence positions within the force, likely with the backing of the Khamenei family.

His father became supreme leader in 1989 and soon Mojtaba Khamenei and his family had access to the billions of dollars and business assets spread across Iran's many bonyads, or foundations funded from state industries and other wealth once held by the shah.

Power rises with his father's

His own power rose alongside his father's, working within his offices in downtown Tehran. US diplomatic cables published by WikiLeaks in the late 2000s began referring to the younger Khamenei as “the power behind the robes.” One recounted an allegation that Khamenei actually tapped his own father's phone, served as his “principal gatekeeper” and had been forming his own power base within the country.

Khamenei “is widely viewed within the regime as a capable and forceful leader and manager who may someday succeed to at least a share of national leadership; his father may also see him in that light,” a 2008 cable read, also noting his lack of theological qualifications and age.

“Mojtaba is, however, due to his skills, wealth, and unmatched alliances, reportedly seen by a number of regime insiders as a plausible candidate for shared leadership of Iran upon his father’s demise, whether that demise is soon or years in the future,” it said.

Khamenei has worked closely with Iran's paramilitary Revolutionary Guard, both with commanders of its expeditionary Quds Force and its all-volunteer Basij that violently suppressed nationwide protests in January, the US Treasury has said.

The United States sanctioned him in 2019 during the first term of USPresident Donald Trump over working to “advance his father’s destabilizing regional ambitions and oppressive domestic objectives.”

That includes allegations that Khamenei from behind the scenes supported the election of hard-line President Mahmoud Ahmadinejad in 2005 and his disputed re-election in 2009 that sparked the Green Movement protests.

Mahdi Karroubi, who was a presidential candidate in 2005 and 2009, denounced Khamenei as “a master's son” and alleged he interfered in both votes. His father reportedly at the time said Khamenei was “a master himself, not a master’s son."

Powers of supreme leader at stake

There has been only one other transfer of power in the office of supreme leader of Iran, the paramount decision-maker since the country’s 1979 revolution. Khomeini died at age 86 after being the figurehead of the revolution and leading Iran through its eight-year war with Iraq.

Now the new leader will come on board after the 12-day war with Israel and as a US-Israeli war with Iran is seeking to eliminate Iran's nuclear threat and military power, hoping also the Iranian people will rise up against the Iranian theocracy.

The supreme leader is at the heart of Iran’s complex power-sharing theocracy and has final say over all matters of state. He also serves as the commander-in-chief of the country’s military and the Guard, a paramilitary force that the United States designated a terrorist organization in 2019, and which his father empowered during his rule.

The Guard, which has led the self-described “Axis of Resistance,” a series of militant groups and allies across the Middle East meant to counter the US and Israel, also has extensive wealth and holdings in Iran. It also controls the country's ballistic missile arsenal.


Iran's 'Axis of Resistance' under Threat after US-Israeli War

Members of Iraq's pro-Iran paramilitary group Kataib Hezbollah march with the group's banners in a funeral for slain fighters killed in a US-Israeli airstrike on their headquarters in al-Qaim near the border with Syria, during a ceremony in Baghdad on March 2, 2026. (AFP)
Members of Iraq's pro-Iran paramilitary group Kataib Hezbollah march with the group's banners in a funeral for slain fighters killed in a US-Israeli airstrike on their headquarters in al-Qaim near the border with Syria, during a ceremony in Baghdad on March 2, 2026. (AFP)
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Iran's 'Axis of Resistance' under Threat after US-Israeli War

Members of Iraq's pro-Iran paramilitary group Kataib Hezbollah march with the group's banners in a funeral for slain fighters killed in a US-Israeli airstrike on their headquarters in al-Qaim near the border with Syria, during a ceremony in Baghdad on March 2, 2026. (AFP)
Members of Iraq's pro-Iran paramilitary group Kataib Hezbollah march with the group's banners in a funeral for slain fighters killed in a US-Israeli airstrike on their headquarters in al-Qaim near the border with Syria, during a ceremony in Baghdad on March 2, 2026. (AFP)

Iran once boasted that it controlled four Arab capitals: Baghdad, Damascus, Beirut and Sanaa in an alliance dubbed the "Axis of Resistance".

But the network -- long used as a regional force against Israel -- has been weakened since the Gaza war and now risks collapse, upending the regional balance, analysts said.

"The axis of resistance is over," said Atlantic Council researcher Nicholas Blanford.

Two days after Hamas launched its October 7, 2023 attack on Israel, Prime Minister Benjamin Netanyahu said his country's response would "change the Middle East".

Backed by Israel's powerful ally, the United States, the Israeli leader did not just intend to defeat the Iran-backed Palestinian group, but the entire axis.

The weakening of Lebanon's Hezbollah after its 2024 war with Israel and the fall of Syrian ruler Bashar al-Assad paved the way for Israel to aim directly at Iran.

Since Saturday, the country has been the target of a major US-Israeli offensive, which even killed Iran's supreme leader Ali Khamenei.

Most of the axis's members like Hezbollah, Yemen's Houthis or Iraqi Shiite groups are "trying to understand how to survive", Renad Mansour, senior research fellow at the Chatham House international affairs think-tank, told AFP.

- 'Defensive approach' -

Since deciding to enter the war by launching rockets at Israel on Monday, Hezbollah brought a major Israeli retaliation, which saw bombings across Lebanon and an Israeli ground incursion to create a buffer zone.

"Naim Qassem doesn't want to get involved in this fight," Blanford, who wrote a book on Hezbollah, said, referring to the group's chief.

However, the analyst said Tehran may have forced Qassem to intervene.

Iraq, a longtime battlefield between Washington and Tehran, saw Iran-backed groups claim dozens of drone attacks on US bases, though many were downed.

To Mansour, these groups lack "the necessary military capabilities to inflict significant damage" while the most prominent ones are now "intertwined in the Iraqi state".

The Houthis in Yemen have so far stayed away from the conflict.

"The Houthis are in a calculated holding pattern, or perhaps a defensive approach," said Ahmed Nagi, senior analyst at the International Crisis Group.

However, Nagi believes that while the axis "is facing an existential threat, that does not necessarily mean it will disintegrate".

"The network operates on more than a military level; its political, social and religious ties remain deeply rooted among its groups and are unlikely to unravel because of battlefield setbacks alone."

The regional upheavals will depend on the outcome of this war, particularly the collapse or survival of the Iranian regime.


Netanyahu’s Political Future at Stake with Iran War, Say Experts

03 March 2020, Israel, Tel Aviv: Israeli Prime Minister Benjamin Netanyahu delivers an address. (dpa)
03 March 2020, Israel, Tel Aviv: Israeli Prime Minister Benjamin Netanyahu delivers an address. (dpa)
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Netanyahu’s Political Future at Stake with Iran War, Say Experts

03 March 2020, Israel, Tel Aviv: Israeli Prime Minister Benjamin Netanyahu delivers an address. (dpa)
03 March 2020, Israel, Tel Aviv: Israeli Prime Minister Benjamin Netanyahu delivers an address. (dpa)

With elections approaching in Israel, the war with Iran has handed Prime Minister Benjamin Netanyahu an opportunity to restore an image deeply scarred by Hamas's October 7, 2023 attack, experts say.

But any political dividend would depend on how the conflict unfolds and how long it lasts, they said according to AFP.

A day after Iran's supreme leader Ali Khamenei was killed in a wave of US-Israeli strikes, Netanyahu said that his close ties with Washington had enabled Israel to "do what I have long aspired to do for 40 years: to strike the terrorist regime decisively".

The Gaza war, sparked by Hamas's unprecedented attack on Israel on October 7, 2023, eroded Netanyahu's popularity.

Critics have accused him of seeking to evade responsibility for the authorities' failure to prevent the deadliest day in Israel's history.

At 76, the leader of the right-wing Likud party is Israel's longest-serving prime minister, with more than 18 cumulative years in office across multiple stints.

Known for his political resilience, Netanyahu has been without a parliamentary majority since the summer, amid a crisis with his ultra-Orthodox religious allies.

He is also standing trial in a long-running corruption case and has sought a presidential pardon, with US President Donald Trump repeatedly pressuring President Isaac Herzog to grant one.

- 'Total victory' -

Elections must be held by October 27 at the latest.

Netanyahu will call early elections, says Emmanuel Navon, a political analyst at Tel Aviv University.

"It's obvious. He won't wait until October given the commemoration of the October 7 anniversary," Navon said.

"If Netanyahu was at rock bottom after the Hamas attack, he has since gradually turned the tide," he added, citing heavy blows dealt by the Israeli military to Hamas, Hezbollah and Iran since the start of the Gaza war.

A Likud party led by Netanyahu would emerge ahead in elections held today, opinion polls suggest.

That would likely see him tasked with forming the next government, though he would still lack a majority with his current allies.

A victory over Iran could change that calculus, experts say.

"This offensive undeniably reinforces the image Netanyahu seeks to cultivate, the one associated with his 'total victory' slogan," independent geopolitical analyst Michael Horowitz told AFP.

"Netanyahu wants to show that this is not a campaign slogan but a reality. It is his national agenda and his electoral strategy," he added.

- 'Iran remains Iran' -

Raviv Druker, a prominent journalist on Channel 13 television, argued that Netanyahu "will try to convince people that the victory is total even if that is an illusion," noting that "Hamas still runs Gaza, and Iran remains Iran even after Saturday's strike".

On the popular news website Walla, journalist Ouriel Deskal went further, suggesting Netanyahu may have chosen the timing of the hostilities to automatically delay -- under a state of emergency -- the March 30 deadline for passing a budget for which he has struggled to secure a majority.

Without a budget, the government would fall on April 1 and elections would be called.

In that scenario, Netanyahu would enter the campaign from a position of weakness.

By contrast "if this war against Iran is a success for Israel, it will be a political victory for Netanyahu," Navon said.

But should the war drag on, the picture could shift dramatically, Horowitz warned.

"Public tolerance for a long war with heavy casualties, combined with a high cost of living, remains extremely low," he said.

During the war last June, Iranian missiles killed 30 people in Israel. Since Saturday, 10 people have been killed in Iran's retaliatory strikes.

"Israel's victories are primarily attributed to the army and to civilian resilience, which enabled the country to wage the longest war in its history," Horowitz noted.

"The army's popularity is rising, not necessarily Netanyahu's."