Israel's Ramon Airport near the southern city of Eilat resumed operations after being briefly shut on Sunday when a drone launched from Yemen struck the arrivals hall, Israel's Airports Authority said.
Two people were injured by shrapnel, the national ambulance service said.
Israel said Yemen's Houthi militias attacked with several drones, most of which were intercepted outside of Israel.
At least one of the drones slipped through Israel's defense system and crashed into the passenger terminal at the airport, the Airports Authority said, blowing out glass windows and sending smoke plumes billowing.
The Houthis claimed responsibility for the strike.
"Following the completion of all safety and security checks, compliance with international civil aviation standards, and receipt of final approval from the Air Force – Ramon Airport has now been reopened for full operations, for both departures and arrivals," the authority said in a statement.
"The first flight from Ramon to Ben Gurion Airport (near Tel Aviv) is expected to depart shortly."
Takeoffs and landings at the airport were halted for around two hours.
Israel's national ambulance service Magen David Adom said a 63-year-old man and a 52-year-old woman were injured by shrapnel and were being evacuated to receive medical treatment.
The airport located near the Red Sea resort city of Eilat mostly handles domestic flights.
Israeli carriers Israir and Arkia had flights scheduled from the airport on Sunday.
The Iran-backed Houthis have been launching missiles and drones thousands of kilometers north towards Israel, in what the group says are acts of solidarity with the Palestinians.
Israel has retaliated by bombing Houthi-controlled areas of Yemen, including Hodeidah port.
