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Weight-Loss Drugs May Lower Cancer Risk in People with Diabetes, a Study Suggests 

A box of Ozempic made by Novo Nordisk is seen at a pharmacy in London, Britain March 8, 2024. (Reuters) 
A box of Ozempic made by Novo Nordisk is seen at a pharmacy in London, Britain March 8, 2024. (Reuters) 
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Weight-Loss Drugs May Lower Cancer Risk in People with Diabetes, a Study Suggests 

A box of Ozempic made by Novo Nordisk is seen at a pharmacy in London, Britain March 8, 2024. (Reuters) 
A box of Ozempic made by Novo Nordisk is seen at a pharmacy in London, Britain March 8, 2024. (Reuters) 

Excess body weight can raise the risk of certain cancers, leading researchers to wonder whether blockbuster drugs like Wegovy, Ozempic and Zepbound could play a role in cancer prevention.

Now, a study of 170,000 patient records suggests there's a slightly lower risk of obesity-related cancers in US adults with diabetes who took these popular medications compared to those who took another class of diabetes drug not associated with weight loss.

This type of study can't prove cause and effect, but the findings hint at a connection worth exploring. More than a dozen cancers are associated with obesity.

“This is a call to scientists and clinical investigators to do more work in this area to really prove or disprove this,” said Dr. Ernest Hawk of MD Anderson Cancer Center in Houston, who was not involved in the study.

The findings were released Thursday by the American Society of Clinical Oncology and will be discussed at its annual meeting in Chicago. The study, funded by the National Institutes of Health, was led by Lucas Mavromatis, a medical student at New York University’s Grossman School of Medicine.

“Chronic disease and chronic disease prevention are some of my passions,” said Mavromatis, a former research fellow with an NIH training program.

GLP-1 receptor agonists are injections used to treat diabetes, and some are also approved to treat obesity. They work by mimicking hormones in the gut and the brain to regulate appetite and feelings of fullness. They don't work for everyone and can produce side effects that include nausea and stomach pain.

In the study, researchers analyzed data from 43 US health systems to compare two groups: people with obesity and diabetes who took GLP-1 drugs and other people with the same conditions who took diabetes drugs like sitagliptin. The two groups were equal in size and matched for other characteristics.

After four years, those who took GLP-1 drugs had a 7% lower risk of developing an obesity-related cancer and an 8% lower risk of death from any cause compared to those who took the other type of diabetes drug. There were 2,501 new cases of obesity-related cancer in the GLP-1 group compared to 2,671 cases in the other group.

The effect was evident in women, but not statistically significant in men. The study couldn't explain that difference, but Mavromatis noted that differences in blood drug concentration, weight loss, metabolism or hormones could be at play.

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Chile Fights Wildfires that Killed 19 and Left 1,500 Homeless

Mirtza Aguilera, right, and her daughter embrace in front of their home burned by wildfires in Tome, Chile, Monday, Jan. 19, 2026. (AP Photo/Javier Torres)
Mirtza Aguilera, right, and her daughter embrace in front of their home burned by wildfires in Tome, Chile, Monday, Jan. 19, 2026. (AP Photo/Javier Torres)
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Chile Fights Wildfires that Killed 19 and Left 1,500 Homeless

Mirtza Aguilera, right, and her daughter embrace in front of their home burned by wildfires in Tome, Chile, Monday, Jan. 19, 2026. (AP Photo/Javier Torres)
Mirtza Aguilera, right, and her daughter embrace in front of their home burned by wildfires in Tome, Chile, Monday, Jan. 19, 2026. (AP Photo/Javier Torres)

Firefighters in Chile are battling forest fires that started on Sunday and have killed at least 19 people and left around 1,500 homeless as they swept through thousands of acres in the center and south of the country, officials said.

Five large wildfires were still active Monday in the South American nation, with temperatures higher than usual due to a summer heatwave, said the National Service for the Prevention of Disasters, The AP news reported.

Chilean President Gabriel Boric declared a state of catastrophe in the central Biobio and neighboring Ñuble regions on Sunday. The emergency designation allows greater coordination with the military to rein wildfires.

Boric said on his X account on Monday morning that weather conditions are adverse, which means some of the fires could reignite.

Wildfires are common in Chile during the summer due to high temperatures and dry weather. The current outbreak of fires in central and southern Chile is one of the deadliest in recent years.

In 2024, massive fires ripping across Chile’s central coastline killed at least 130 people, becoming the nation’s deadliest natural disaster since a devastating 2010 earthquake.

 

 

 

 

 

 

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Nepal Halts Search after Guide Killed, Iranian Climber Missing

A tourist looks at a view of Mt. Everest from the hills of Syangboche in Nepal December 3, 2009. REUTERS/Gopal Chitrakar
A tourist looks at a view of Mt. Everest from the hills of Syangboche in Nepal December 3, 2009. REUTERS/Gopal Chitrakar
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Nepal Halts Search after Guide Killed, Iranian Climber Missing

A tourist looks at a view of Mt. Everest from the hills of Syangboche in Nepal December 3, 2009. REUTERS/Gopal Chitrakar
A tourist looks at a view of Mt. Everest from the hills of Syangboche in Nepal December 3, 2009. REUTERS/Gopal Chitrakar

Bad weather forced Nepali rescuers to suspend the search Monday for an Iranian climber missing for four days after an accident which killed a Nepali team member, expedition organizers said.

Extreme conditions, including fierce winds, made rescue efforts impossible on the 8,481-meter (27,825-feet) high Mount Makalu, the world's fifth highest mountain.

Iranian climber Abolfazl Gozali, 42, and Nepali guide Phurba Ongel Sherpa, 44, were part of a rare winter expedition on the peak.

The four-member team successfully summited on Thursday, but during the descent the guide fell to his death.

Team lead Sanu Sherpa, who has climbed all 14 highest peaks in the world at least twice, and Lakpa Rinji Sherpa went to his aid but found that he had fallen hundreds of meters and did not survive.

When they returned to where they had left Gozali, he was no longer there.

"A team of eight experienced climbers have been sent but the wind has been very strong and affected the search," Madan Lamsal of expedition organizer Makalu Adventure told AFP.

"We hope to resume soon."

Lamsal said the rescuers intend to find Gozali, as well as recover the guide's body.

Phurba Ongel Sherpa was a highly experienced mountaineering guide with multiple summits of Everest and other major peaks.

Gozali is also an accomplished climber, who has climbed two of world's highest peaks and completed the "snow-leopard peaks" -- the five mountains of over 7,000 meters between Tajikistan and Kyrgyzstan.

This was his second attempt to summit Makalu in winter. Last year, freezing temperatures and high winds forced the team to turn back, just 800 meters short of the summit.

Nepal is home to eight of the world's 10 highest peaks, including Mount Everest, and welcomes hundreds of climbers every year during the spring and autumn climbing seasons.

Dangerous terrain and extreme weather can make winter expeditions particularly risky.

Varieties

Shark Mauls Surfer in Sydney, 3rd Attack in Two Days

People stand next to warning signs in place, and beaches are closed after a surfer suffered a shark attack at Dee Why Beach in Sydney, Australia, January 19, 2026. REUTERS/Jeremy Piper
People stand next to warning signs in place, and beaches are closed after a surfer suffered a shark attack at Dee Why Beach in Sydney, Australia, January 19, 2026. REUTERS/Jeremy Piper
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Shark Mauls Surfer in Sydney, 3rd Attack in Two Days

People stand next to warning signs in place, and beaches are closed after a surfer suffered a shark attack at Dee Why Beach in Sydney, Australia, January 19, 2026. REUTERS/Jeremy Piper
People stand next to warning signs in place, and beaches are closed after a surfer suffered a shark attack at Dee Why Beach in Sydney, Australia, January 19, 2026. REUTERS/Jeremy Piper

A shark mauled a surfer off an ocean beach in Sydney on Monday in the Australian city's third shark attack in two days, authorities said.

The surfer, believed to be in his 20s, was in a critical condition in hospital with serious leg injuries after the attack at a northern Sydney beach, police said.

"The man was pulled from the water by members of the public who commenced first aid before the arrival of emergency services," New South Wales state police said in a statement.

All of Sydney's northern beaches were closed until further notice.

The attack at North Steyne Beach in the suburb of Manly came hours after a shark bit a large chunk out of a young surfer's board about 4 kilometers (2.5 miles) north along the coast at Dee Why Point.

That surfer, reportedly a boy aged about 11, was uninjured but the beach was closed immediately, AFP reported.

On Sunday, a large shark bit a 12-year-old boy in the legs as he played with friends at a beach in Sydney harbor, leaving him fighting for survival in hospital.

The boy and his friends were jumping from a six-meter (20-foot) rock into the water off Shark Beach in the eastern suburb of Vaucluse when the predator struck, police said.

"It was a horrendous scene at the time when police attended. We believe it was something like a bull shark that attacked the lower limbs of that boy," said Superintendent Joseph McNulty, New South Wales marine area police commander.

"That boy is fighting for his life now," he told reporters on Monday.

Recent heavy rain had drained into the harbor, and authorities believed the combination of the brackish seawater and the children's splashing created a "perfect storm" for a shark attack, McNulty said.

He warned people not to go swimming in the harbor or other river systems in New South Wales because of the risks.

He praised the boy's "brave" young friends for pulling him out of the water on Sunday.

Officers put the unconscious child in a police boat and gave him first aid, applying two tourniquets to stem the bleeding from his legs, McNulty said.

They tried to resuscitate the boy as they sped across the harbor to a wharf where ambulance paramedics were waiting.

The child, confirmed by police to be 12 years old, was in intensive care at Sydney Children's Hospital surrounded by family and friends, McNulty said.