Egypt instructed all of its airlines to avoid Iranian air space for a three-hour period in the early morning on Thursday amid tension between Israel and Iran.
The NOTAM, a safety notice provided to pilots on Wednesday, said the instruction would be in effect from 0100-0400 GMT.
"All Egyptian carriers shall avoid overflying Tehran (Flight information Region) FIR. No flight plan will be accepted overflying such territory," the notice said, referring to the three-hour period provided.
On Sunday, Jordanian authorities asked all airlines landing at its airports to carry 45 minutes worth of extra fuel.
Many airlines are revising their schedules to avoid Iranian and Lebanese air space while also calling off flights to Israel and Lebanon as many fear a possible broader conflict after the killing of senior members of armed groups Hamas and Hezbollah.
Countries in the region, including Jordan, closed their airspace earlier this year amidst aerial attacks on Israel.